(S,S) Bisoleoyl-lysobisphosphatidic acid (LBPA)

Product Number: L-B181

$106.00$378.00

$106.00
$378.00
SKU: L-B181- Category: Tags: ,

Lysobisphosphatidic acids (LBPAs), known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue, and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular, often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport. (S,S) Bisoleoyl-lysobisphosphatidic acid is the naturally occurring, biologically active isomer of LPBA.


Publications

1) Abe, A, Shayman, J.A. (2009) “The role of negatively charged lipids in lysosomal phospholipase A2 function.” Journal of Lipid Research. 50(10): 2027-35.
2) Chevallier, J. et al. (2008) “Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels” Journal of Biological Chemistry. 283: 27871-27880
3) Yang, S-T. et al (2010) “Cell-Penetrating Peptide Induces Leaky Fusion of Liposomes Containing Late Endosome-Specific Anionic Lipid” Biophysical Journal. 8(20): 2525–2533
4) Alvira, D. et al. (2011) “Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein” Journal of Biological Chemistry. 286: 32313-32323.
5) Bissig, C. et al. (2013) “Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX” Cell. 25(4): 364-373.
6) Baptist, M., et al. (2015). “2,2-Bis(monoacylglycero) PO4 (BMP), but Not 3,1-BMP, Increases Membrane Curvature Stress to Enhance α-Tocopherol Transfer Protein Binding to Membranes.” Lipids January: 1-6.

Categories

Lipids

Filter

LBPA, Lysophospholipid

CAS Number

288089-44-1

Molecular Formula

C58H114NO10P

Molecular Weight (g/mol)

1016.5

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

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