Molecular Weight: 3347.66
Salt Form: TFA
Sequence (3-letter): Ala-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Ile-Tyr-Asp-Ile-Leu-Arg-Gly-Thr-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Cys4-Cys10, Cys5-Cys12)
Sequence (1-letter): APDCCRQKTCSCRIYDILRGTGNHAAGILTL-NH2
Storage: -20 °C or below
Orexin A and Orexin B are neuropeptides produced in the lateral and posterior hypothalmus. They bind the OX1 and OX2 GPCRs which are involved in food uptake. Orexin A binds to OX1 & OX2 with equal affinity while Orexin B primarily binds to OX2. In addition the Orexins have been shown to have roles in wakefulness, mood, addiction, and lipid metabolism.