Isopentenyl thiolodiphosphate (ISPP) is an analog of IPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.
Provided as the tris-ammonium salt
Featured In Publications
1. Phan, R. M. and C. D. Poulter (2001). “Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors.” The Journal of Organic Chemistry 66(20): 6705.
2. Lee, L. V., B. Granda, et al. (2010). “Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase.” Biochemistry 49(25): 5366.
3. Sandoval, C., M. Ayson, et al. (2014) “Use of pantothenate as a metabolic switch increases the genetic stability of farnesene producing Saccharomyces cerevisiae” Metabolic Engineering 25, 215-226.
4. Chan, YT, TP Ko, et al. (2017) “Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase” ACS Omega, 2(3), 930-936.
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