Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), aka IP4, is produced from Ins(1,4,5)P3 in stimulated cells by IP3 3-kinase (Itpkb). IP4 acts in conjunction with IP3 to mobilize intracellular calcium. In addition, IP4 has roles in T cell precursor development and responsiveness and thymocyte reactivity to antigens.
“Phosphatidylinositol and inositol phosphate metabolism.” J. Cell Sci. 2001, 114, 2207-8.
Keywords: D-myo-Inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4, I(1,3,4,5)P4, InsP4, or IP4
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