GroPI(4,5)P2

Product Number: P-4500

$141
$432
$745

Glycerophosphoinositol 4,5-diphosphate (GroPI(4,5)P2) is a synthetic, purified PI(4,5)P2 without acyl chains at the 1- and 2-positions of the glycerol.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories

Lipids

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Glycerolphosphoinositide, Phosphoinositides

CAS Number

111188-72-8

Molecular Formula

C9H16Na5O17P3

Molecular Weight (g/mol)

604.1

Purity

>95%

Storage

-20 °C or below

Shipping Temp

Dry ice or gel ice depending on destination

Technical Data Sheet

1) Zizza, P., C. Iurisci, et al. (2012). “Phospholipase A2 IValpha regulates phagocytosis independent of its enzymatic activity.” J Biol Chem 287(20): 16849-16859.

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