Fluorescein Cardiolipin

Fluorescein cardiolipin is a fluorescent analog of cardiolipin labeled at the end of the sn-1 chain.
Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane¹. In humans, CL is made by cardiolipin synthase from phosphatitydlglycerol and cytidinedisphosphate-diacylglycerdol². Due to its four acyl chains and small head group, CL can organize into domains which can be proton sinks, fill cavities at protein interfaces, stabilize protein oligomers, and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus³.