Molecular Weight: 1041.47
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH
Sequence (1-letter): Dnp-PLAYWAR-OH
Storage: -20 °C or below
Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH is a fluorogenic substrate for matrix metalloprotease 8 (MMP-8) and MMP-26. MMP-8 (neutrophil collagenase) primarily degrades type I, II, & III collagen in the extracellular matrix. Reduced MMP-8 activity in a murine breast cancer model leads to increased tumor growth and vascularity in addition to immune cell infiltration.
Activity is quantified by tryptophan fluorescence (Ex 280 nm, Em at 360 nm).
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