Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH (MMP-8 Substrate)

Product Number: 868-44


Molecular Weight: 1041.47
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH
Sequence (1-letter): Dnp-PLAYWAR-OH
Storage: -20 °C or below

Dnp-Pro-Leu-Ala-Tyr-Trp-Ala-Arg-OH is a fluorogenic substrate for matrix metalloprotease 8 (MMP-8) and MMP-26. MMP-8 (neutrophil collagenase) primarily degrades type I, II, & III collagen in the extracellular matrix. Reduced MMP-8 activity in a murine breast cancer model leads to increased tumor growth and vascularity in addition to immune cell infiltration.

Activity is quantified by tryptophan fluorescence (Ex 280 nm, Em at 360 nm).





Enzyme Substrates

Shipping Temp

Ambient Temperature


-20 °C or below

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