Calmodulin Kinase II Inhibitor (281-309)

Product Number: 893-40

$261

CAS Number: 116826-37-0
Molecular Weight: 3371.86
Salt Form: Acetate
Purity: >96%
Sequence (3-letter): Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
Sequence (1-letter): MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
Storage: -20 °C or below

Calmodulin Kinase II Inhibitor (281-309) [CaMKII(281-309)] is a peptide fragment containing the calmodulin binding site (290-309) and the phosphorylation site (Thr286). CaMKII(281-309). It is useful as a calmodulin binding peptide and can act as an inhibitor of CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site. Alternative name: Calmodulin Dependent Protein Kinase II (281-309)

References

Waxham MN, Aronowski J (1993) “Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro”. Biochemistry 32(11):2923-30

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