BrP-LPA

Product Number: L-7416

$152
$685

BrP-LPA, aka LPA bromophosphonate, acts as both an Autotaxin inhibitor (94% inhibition at 10 μM) and pan LPA receptor antagonist (LPA1: 1.5 μM, LPA2: 1.4 μM, LPA3: 1.2 μM, LPA4: 0.27 μM). BrP-LPA inhibits the invasiveness of NIH3T3 ras ATX cells by 40% and decreases chemotaxis by 23%. BrP-LPA reduces the size of breast (MDA-MB-231), colon (HCT-116) and melanoma (B16F10) tumors in mouse models. It also attenuates collagen-induced arthritis PPARγ is not activated by BrP-LPA.


Publications

1) Jiang, G., Y. Xu, et al. (2007). “Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA.” ChemMedChem 2(5): 679-90.
2) Zhang, H., X. Xu, et al. (2009). “Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo.” Cancer Res 69: 5441
3) Schleicher, S. M., D. K. Thotala, et al. (2011). “Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature.” PLoS ONE 6(7): e22182.
4) Nikitopoulou, I., E. Kaffe, et al. (2013). “A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis.” PLoS ONE 8(7): e70941

Categories

Biochemical Reagents

Filter

Autotaxin, Inhibitor, Lysophosphatidic Acid

CAS Number

944265-88-7

Molecular Formula

C20H39BrNaO6P

Molecular Weight (g/mol)

509.4

Purity

95%

Storage

-20 °C or below

Technical Data Sheet

You may also like…

  • FS-3 (LysoPLD / Autotaxin fluorogenic substrate) - Echelon Biosciences
    Biochemical Reagents

    FS-3 (LysoPLD / Autotaxin substrate)

    Product Number: L-2000

    $345$2,788 View products
  • HA130 (Autotaxin Inhibitor) - Echelon Biosciences
    Biochemical Reagents

    HA130 (Autotaxin Inhibitor)

    Product Number: B-0701

    $64$120 View products
  • Antibodies & Proteins

    Autotaxin Enzyme, active

    Product Number: E-4000

    $101$477 View products
  • ATX-Red AR-2, in vivo autotaxin probe - Echelon Biosciences
    Biochemical Reagents

    ATX-Red AR-2

    Product Number: L-2010

    $106$813 View products
Shopping Cart
Scroll to Top

Technical Support

Bulk & Custom Orders