BODIPY FL PI(3,4)P2

Product Number: C-34F6

$542
$934

(BODIPY FL Phosphatidylinositol 3,4-bisphosphate) is a water soluble analog of PI(3,4)P2 labeled with the green fluorophore, Bodipy®-FL at the sn-1 position.


Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Bulk discounts available, please email echelon@echelon-inc.com for information.


Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(3,4)P2

Excitation/Emission

503/513 nm

Molecular Formula

C67H134BF2N8O20P3

Molecular Weight (g/mol)

1,513.55

Purity

>95%

Storage

-20 °C or below, protect from light

Shipping Temp

Dry ice or gel ice depending on destination

Technical Data Sheet

1. Oganesian, A., M. Poot, et al. (2003). “Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.” Proc Natl Acad Sci U S A 100(13): 7563-8.
2. Rowe, T., et al. (2006). “A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.” Assay Drug Dev Technol 4(2): 175-183.
3. Caromile, L. A., A. Oganesian, et al. (2010). “The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.” J Biol Chem 285(14): 10487-96.

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