ATX100 is a biodegradable ionizable lipid with improved in vivo activities for siRNA delivery via lipid nanoparticles (LNP). The physicochemical parameters of ATX100: pKa 6.316, lipophilicity cLogD 14.03, nanoparticle size 82 nm. The in vivo factor VII knockdown efficiency of ATX100 is 97% (0.03mg/kg in mice, i.v.).
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 2230647-37-5 |
| Molecular Formula | C44H86N2O5S |
| Molecular Weight (g/mol) | 755.24 |
| Purity | >95% |
| Storage | -20 °C or below |
