Alkyl-OMPT (D-sn-1-O-oleyl-2-O-methyl-glyceryl-3-phosphothionate) is a potent agonist for the G-protein-coupled LPA 3 receptor. Alkyl OMPT induces cell migration in cancer cells mediated by activation of LPA1. Alkyl OMPT also activated Ca2+ release via LPA2 activation but with reduced potency relative to sn-1-oleoyl LPA.
Agonist, Lysophosphatidic Acid, Lysophospholipid
|Molecular Weight (g/mol)||
-20 °C or below
1) Yanagida, K., K. Masago, et al. (2009). “Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6.” Journal of Biological Chemistry 284(26): 17731-17741.
2) Prestwich, G., Y. Xu, et al. (2005). “New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.” Biochem Soc Trans 33: 1357–1361.
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