CAS Number: 292633-16-0
Molecular Weight: 711.3
Salt Form: N/A
Sequence (3-letter): Ac-Leu-Glu-His-Asp-AMC
Sequence (1-letter): Ac-LEHD-AMC
Storage: -20 °C or below
Ac-Leu-Glu-His-Asp-AMC is a fluorogenic substrate for Caspase 9. Caspase 9 is a cysteine protease which acts as an initiating enzyme in apoptosis pathways. It activates Caspases 3, 6, & 7.
Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.