Ac-Asp-Glu-Val-Asp-4MbNA (Caspase 3 (Apopain) Substrate)

Product Number: 861-18

$144
$537

Molecular Weight: 673.26
Salt Form: Acetate
Purity: >96%
Sequence (3-letter): Ac-Asp-Glu-Val-Asp-4MbNA
Sequence (1-letter): Ac-DEVD-4MbNA
Storage: -20 °C or below

Ac-Asp-Glu-Val-Asp-4MbNA is a fluorogenic substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that preferentially cleaves substrates built on VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells.

Activity is quantified by release of free fluorescent 4-Methoxy-β-naphthylamine (4MβNA) which excites at 335-350 nm and emits at 410-440 nm

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Ambient Temperature

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-20 °C or below

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