Ac-Arg-Gly-Phe-Phe-Pro-AFC (Cathepsin D Substrate, fluorogenic)

Product Number: 874-19

$211.00

$211.00
SKU: 874-19 Category: Tag:

Molecular Weight: 875.91
Salt Form: TFA
Purity: >95%
Sequence (3-letter): Ac-Arg-Gly-Phe-Phe-Pro-AFC
Sequence (1-letter): Ac-RGFFP-AFC
Storage: -20 °C or below

Ac-Arg-Gly-Phe-Phe-Pro-AFC is a fluorogenic substrate for cathepsin D. Cathepsin D is a lysosomal aspartyl protease whose role is to degrade and activate intracellular proteins including hormones, enzyme precursors, and growth factors. Over expression in tumors stimulates metastasis and considered a marker of poor prognosis in breast cancer.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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