a-Secretase Substrate

Product Number: 640-55


SKU: 640-55 Category: Tags: ,

Molecular Weight: 2116.1
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Ac-Arg-Glu(EDANS)-Val-His-His-Gln-Lys-Leu-Val-Phe-Lys(Dabcyl)-Arg-OH
Sequence (1-letter): Ac-RE(EDANS)VHHQKLVFK(Dabcyl)R-OH
Storage: -20 °C or below

a-Secretase Substrate is an internally quenched fluorogenic peptide containing the α-secretase cleavage site of β-Amyloid Precursor Protein (APP). Cleavage occurs at the Lys-Leu bond and fluorescence can be measured at 490 nm.

Komano H, Seeger M, Gandy S, Wang GT, Krafft GA, Fuller RS. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. J Biol Chem. 1998 Nov 27;273(48):31648-51. doi: 10.1074/jbc.273.48.31648. PMID: 9822624

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com





Alzheimer's, Central Nervous System

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