4A3-SCC-10

Product No: N-1430

$225
$385
$725
$1,875

The linker-degradable ionizable lipid (LDIL) 4A3-SCC-10 possesses superior endosomal escape and rapid mRNA release abilities thanks to its unique GSH-responsive cone-shaped architecture. Lipid nanoparticles (LNPs) of 4A3-SCC-10 showed improved mCherry mRNA delivery in livers by 87-fold compared to DLin-MC3-DMA in vivo. 4A3-SCC-10 also demonstrated improved mRNA delivery in vivo, compared to its parent counterpart without a disulfide bond or control counterpart with a disulfide bond in the tail.

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Lipids

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Ionizable/Cationic Lipids

Molecular Formula

C91H171N3O16S12

Molecular Weight (g/mol)

1948.09

Purity

>90%

Shipping Temp

Ambient Temperature

Storage

-20 °C or below

Technical Data Sheet

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