The linker-degradable ionizable lipid (LDIL) 4A3-SCC-10 possesses superior endosomal escape and rapid mRNA release abilities thanks to its unique GSH-responsive cone-shaped architecture. Lipid nanoparticles (LNPs) of 4A3-SCC-10 showed improved mCherry mRNA delivery in livers by 87-fold compared to DLin-MC3-DMA in vivo. 4A3-SCC-10 also demonstrated improved mRNA delivery in vivo, compared to its parent counterpart without a disulfide bond or control counterpart with a disulfide bond in the tail.
Product No: N-1430
N-1430
4A3-SCC-10
The linker-degradable ionizable lipid (LDIL) 4A3-SCC-10 possesses superior endosomal escape and rapid mRNA release abilities thanks to its unique GSH-responsive cone-shaped architecture. [Read More...]
