2S-OMPT

Product Number: L-9418

$79
$488

OMPT [L-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate] is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.

Categories

Biochemical Reagents

Filter

Agonist, Lysophosphatidic Acid, Lysophospholipid

CAS Number

645408-61-3

Molecular Formula

C22H43O6PS

Molecular Weight (g/mol)

466.61

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

1) Lin, D. A. and J. A. Boyce (2005). “IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells.” J Immunol 175(8): 5430-8.
2) Zhao, C., M. J. Fernandes, et al. (2008). “Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?” Mol Pharmacol 73(2): 587-600.
3) Qian, L., Y. Xu, et al. (2003). “Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.” J Med Chem 46(26): 5575-8.

You may also like…

  • Oleoyl LPA, 18:1 LPA - Echelon Biosciences
    Lipids

    Oleoyl LPA, 18:1 LPA

    Product Number: L-0181

    $20$160 View products
  • Ki16425 (LPA Receptor Antagonist)
    Biochemical Reagents

    Ki16425 (LPA Receptor Antagonist)

    Product Number: B-0730

    $60$461 View products
  • Kits & Assays

    Lysophosphatidic Acid ELISA Kit

    Product Number: K-2800S

    $969 View products
  • BrP-LPA (LPA bromophosphonate) - Echelon Biosciences
    Biochemical Reagents

    BrP-LPA

    Product Number: L-7416

    $152$685 View products
Shopping Cart
Scroll to Top

Technical Support

Bulk & Custom Orders