2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers, (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release, IL-6 production, and MAPK and Akt phosporylation in OVCAR3 cells.
D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate (2R-OMPT)
Product Number: L-9318
Powered by Bioz| Categories | Biochemical Reagents |
|---|---|
| Filter | Agonist, Lysophosphatidic Acid, Lysophospholipid |
| CAS Number | 645408-60-2 |
| Molecular Formula | C22H43O6PS |
| Molecular Weight (g/mol) | 466.61 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Qian, L., Y. Xu, et al. (2003). “Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.” J Med Chem 46(26): 5575-8.
2) Altman, M. K., V. Gopal, et al. (2010). “Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.” Mol Cancer 9: 140.
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