1-Stearoyl-2-arachidonoyl-sn–glycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-arachidonoyl-sn–glycerol is a diacylglycerol is a potent activator of PKCα, PKCε, and PKCδ and also competitively binds to the Ras activator RasGRP. 1,2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4,5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC), which is a key regulator of signal transduction, cellular regulation, and tumor promotion.
References
1) Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M., (1985), “Exogenous sn-1,2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets“, J. Biol. Chem. 260, 1358-1361.
2) Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M., (1986), “Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols“, Proc. Natl. Acad. Sci. USA 83, 1184-1188.
