1-Stearoyl-2-Arachidonoyl-sn-Glycerol

Product Number: L-0024

$58.00$183.00

$58.00
$183.00
SKU: L-0024aa Category: Tags: , , ,

1-Stearoyl-2-arachidonoyl-snglycerol is a diacylglycerol (DAG) with polyunsaturated fatty acid arachidonic acid and stearic acid in the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-arachidonoyl-snglycerol is a diacylglycerol is a potent activator of PKCα, PKCε, and PKCδ and also competitively binds to the Ras activator RasGRP. 1,2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4,5-bisphosphate by Phospholipase C. DAGs activate Protein Kinase C (PKC), which is a key regulator of signal transduction, cellular regulation, and tumor promotion.

References

1) Lapetina, E.G., Reep, B., Ganong, B.R. & Bell, R.M., (1985), “Exogenous sn-1,2-diacylglycerols Containing Saturated Fatty Acids Functions as Bioregulators of Protein Kinase C in Human Platelets“, J. Biol. Chem. 260, 1358-1361.

2) Ganong, B.R., Loomis, C.R., Hannun, Y.A. & Bell, R.M., (1986), “Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols“, Proc. Natl. Acad. Sci. USA 83, 1184-1188.

Categories

Lipids

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Diacylglycerol

CAS Number

65914-84-3

Molecular Formula

C41H72O5

Molecular Weight (g/mol)

645.01

Purity

95%

Storage

-80 °C

Technical Data Sheet

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