MEP Antibacterial Screening Service

The methylerythritol phosphate (MEP) pathway, is utilized by most bacteria, including all Gram-negatives and many Gram-positives, and plant chloroplasts while the mevalonate pathway is found in humans, plant cytosol and some Gram-positive bacteria.  Due to this natural distribution, the MEP pathway represents a promising target for development of novel antibacterial agents and herbicides.

  • Echelon has 25 years of assay development expertise and 15 years experience in the MEP field.
  • Your samples are cataloged and stored according to your requirements.
  • The MEP Screening Service consists of two screens; a primary screen to  identify “hits” of greater than 50% inhibition and a secondary screen to test any inhibitor identified in the first screen for specificity towards the MEP pathway. 
  • Usually, results are provided 2 weeks from receipt of samples. We can accommodate tighter schedules if needed.

Contact us for a quote on your custom assay service.


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Publications for this service are based off of the MEP Synthase Inhibitor Screen (catalog number K-2000C), the product used for this assay service.

1) Bochar, D.A.; Freisen, J.A.; Stauffacher, C.V. and Rodwell, V.W.(1999) Comprehensive Natural Products Chemistry,(Cane, D. Ed.) Pergamon Press, Oxford, pp. 15-44.
2) Sacchettini, J.C. and Poulter, C.C. (1997) Science, 277(5333), 1788-9.
3) Testa, C.A.; Brown, M.J. (2003) Current Pharmceutical Biotechnology, 4, 248-259.
4) Koppisch, A.T.; Fox, D.T.; Blagg, B.; Poulter, C.D. (2002), Jan 8; 41 (1), 236-43.

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