The concept of biological, intracellular phase separation has existed for some time. However, until recently direct evidence for this phenomenon …
Phase-separated condensates may be microdomains for unique lipid biology Read More »
Interleukin-17 (IL-17) is a cytokine produced by a specific type of T cell and is involved in restricting invasive microbes. …
A phosphatidylinositol kinase could be a new target for autoimmune therapy Read More »
Communication between neurons in the brain, neurotransmission, is dependent on the release of small molecules from specialized structures called synaptic …
Exo-endocytic coupling in neurons is dependent on lipid signaling Read More »
Bis(monoacylglycero)phosphate (BMP), also known as LBPA, is necessary for lysosomal function and alterations in BMP levels have been observed in …
Disease-associated protein CLN5 is identified as the long-sought BMP synthase Read More »
Calcium homeostasis in the body is critically important for maintaining bone mass and muscle contraction including cardiac contractility. Circulating levels …
TRPV5 calcium channels use alternative ligands in the absence of phosphoinositides Read More »
In mammals, the well-being of offspring can be influenced by the maternal diet and environment. However, it is not clear …
Maternal transfer of sphingosine 1-phosphate is neuroprotective in offspring Read More »
α-Synuclein (α-Syn) has long been associated with neurodegeneration due to its presence in abnormal protein aggregates found in the brains …
Parkinson’s disease associated α-Synuclein can modulate clathrin lattice size Read More »
The development of kinase inhibitors has received significant attention, with relatively little emphasis on creating pharmacological kinase activators. This is …
Novel PI3Kα activator offers new therapeutic potential Read More »
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