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Insights / Resources
Stay informed with our informative blog posts and resources.
Inhibitor Screening with a Hyaluronidase Activity ELISA
Hyaluronic acid (HA) is a fascinating bioactive polymer involved in various cellular signaling pathways. It has been extensively s
Discover SENT-Seq & its Impact on LNPs
Using single cell RNA sequencing to identify novel lipid nanoparticle candidates with Dr. Kalina Paunovska, co-founder of Nava The
Decoding Lipid-Immune Interactions/ Insights from Dr. Ganesh Halade’s Webinar
This webinar focused on the fundamental role of bioactive lipids in resolving inflammation and preventing chronic inflammation. Th
Lipid Nanoparticles: Formulation Concepts + Guidance
The advent of the vaccines for SARS-COV-2 / COVID19 has generated an explosion in interest in creating new medicines based on thei
Lipid mediated intracellular organization of synaptic assembly
Proper nervous system function relies on small junctions between neurons that allow for communication. These are called synapses.
Addition of anti-inflammatory lipids blocks toxicity from pDNA-LNPs
Interest in ionizable lipids and lipid nanoparticles (LNPs) continues to accelerate, and as the field grows novel cargos and lipid
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Upcoming Events
Webinar with Dr. Richard Anderson December 10th 11am EST
“A Marriage Between p53 and PI 3-Kinase Signaling Reveals a Third Messenger Signaling pathway in Cancer”
Phosphoinositide lipids (PIPs) are second messengers that modulate most biological processes and have fundamental roles in multiple human diseases. These PIPs are phosphorylated on the inositol head group generating seven distinct PIP second messengers that are spatially organized to regulate membrane trafficking, cell migration and invasion, cell stress pathways, cell proliferation and cell death. In the canonical PIP pathways, the PIPs are organized as lipids immersed in membrane compartments with the PIP myo-inositol head at the cytoplasmic interface. Remarkably the PIPs also become covalently linked at a repertoire of regulatory proteins in cells. These PIP linked proteins are both nuclear and cytoplasmic. The founding member is p53. Now we know that p53 becomes initially linked to a PI likely through the glycerol backbone. The p53-PI is then acted on by PIP kinases and phosphatases ultimately generating a p53-phosphoinositol-3,4,5-trisphosphate (p53-PIP3) signalosome that activates a nuclear Akt pathway that appears key for p53’s roles in cancer. We have named this PIP linked pathway a third messenger pathway. This new pathway involves many regulatory proteins that will require novel approaches to detect the PIP linkage on proteins, and these have clear diagnostic and therapeutic possibilities that will be discussed.
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Biosciences