VPC 23019 (S1P1/3 Antagonist)

Product Number: B-0061

$62.00$314.00

$62.00
$219.00
$314.00

Sphingosine-1-phosphate (S1P) is a versatile signaling molecule, which is produced by phosphorylation of sphingosine by two distinct sphingosine kinases, SphK1 and SphK2. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, survival, and has a role in regulation cell shape and Ca2+ homeostasis. VPC23019, an analog of FTY720 (Fingolimod, Gilenya), is a potent anatagonist of the S1P1 & S1P3 receptors. VPC23019 will inhibit the migration of various types of cancer cells.

References

1) M. D. Davis, J. J. Clemens, T. L. Macdonald, et al. “Sphingosine 1-phosphate analogs as receptor antagonists.” The Journal of Biological Chemisty, 280 (2005), 9833-9841.
2) R.J. Watters, H-G. Wang, et al. “Targeting Sphingosine-1-Phosphate Receptors in Cancer” Anticancer Agents Med Chem., 11 (2011), 810-817.


Categories

Biochemical Reagents

Filter

Inhibitor, Sphingolipid

CAS Number

449173-19-7

Molecular Formula

C17H29N2O5P

Molecular Weight (g/mol)

372.18

Storage

-20 °C or below

Technical Data Sheet

You may also like…

Shopping Cart
Scroll to Top