Purified Anti-PtdIns(3,4)P2 antibody
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay
Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.
1) Bae, Y. H., Z. Ding, et al. (2010). “Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.” Proceedings of the National Academy of Sciences.