Purified Anti-PtdIns(3,4)P2 IgG

Purified Anti-PtdIns(3,4)P2 antibody
Subtype: IgG3
Source: Mouse
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay

Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

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Publications

1) Bae, Y. H., Z. Ding, et al. (2010). “Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.” Proceedings of the National Academy of Sciences.