4-Methylumbelliferone (HA Synthase Inhibitor)

Product Number: JK201388

$19.00$192.00

$60.00
$192.00
$19.00

4-Methylumbelliferone (4-MU) is a derivative of umbelliferone which naturally occurs in plants. 4-MU been used as a building block for florescence probes. It has antineoplastic properties and is an approved drug with the name “hymecromone” for managing biliary spasm in Europe and Asia1. Recently, it has been found to inhibit hyaluronic acid synthase leading to lower levels of circulating HA2.

References

Nagy, N.; Kuipers, H. F.; Frymoyer, A. R.; Ishak, H. D.; Bollyky, J. B.; Wight, T. N.; Bollyky, P. L., 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol 2015, 6, 123.

Sukowati, C. H. C.; Anfuso, B.; Fiore, E.; Ie, S. I.; Raseni, A.; Vascotto, F.; Avellini, C.; Mazzolini, G.; Tiribelli, C., Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis. Sci Rep 2019, 9 (1), 4026.


Categories

Biochemical Reagents

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Activity, Hyaluronic Acid, Inhibitor

CAS Number

90-33-5

Molecular Formula

C10H8O3

Molecular Weight (g/mol)

176.17

Purity

>95%

Storage

Room temperature

Technical Data Sheet

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