4-Methylumbelliferone (HA Synthase Inhibitor)

Product Number: JK201388

Support

4-Methylumbelliferone (4-MU) is a derivative of umbelliferone which naturally occurs in plants. 4-MU been used as a building block for florescence probes. It has antineoplastic properties and is an approved drug with the name “hymecromone” for managing biliary spasm in Europe and Asia¹. Recently, it has been found to inhibit hyaluronic acid synthase leading to lower levels of circulating HA².

References

Nagy, N.; Kuipers, H. F.; Frymoyer, A. R.; Ishak, H. D.; Bollyky, J. B.; Wight, T. N.; Bollyky, P. L., 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol 2015, 6, 123.

Sukowati, C. H. C.; Anfuso, B.; Fiore, E.; Ie, S. I.; Raseni, A.; Vascotto, F.; Avellini, C.; Mazzolini, G.; Tiribelli, C., Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis. Sci Rep 2019, 9 (1), 4026.

Categories	Biochemical Reagents
Filter	Activity, Hyaluronic Acid, Inhibitor
CAS Number	90-33-5
Molecular Formula	C10H8O3
Molecular Weight (g/mol)	176.17
Purity	>95%
Storage	Room temperature