1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) (16:0 LysoPG) is a form of lysophosphatidylglycerol (LPG), which increases intracellular Ca2+ release and induces phosphorylation on ERK and Akt in OVCAR3 cells however the exact receptor has not been identified. LPG can also modulate the formyl peptide like-1 activated inflammatory response in human phagocytes. Lysophospholipids are lipid mediators which elicit a diverse array of cellular responses through activation of phospholipid specific G protein-coupled receptors.
16:0 LysoPG (LPG)
Product Number: L-5216
|Molecular Weight (g/mol)||
-20 °C or below
1). K. Makide, et al “Novel lysophosphoplipid receptors: their structure and function” Journal of Lipid Research, 2014, 55, 1986;
2) J.W. Shim, et al. “Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1? production from human phagocytes” Exp. Mol. Med., 2009, 41, 584-591.
3) K.S Park, et al. “Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor.” Biochem. Pharmacol., 2007, 73, 675-81.