Lipid Binding Proteins
| Protein Name | Description | Interacting Lipids | Reference | Uniprot |
|---|---|---|---|---|
| CHM7 | Putative component of the ESCRT complex. | Phosphatidic Acid | Thaller et al. 2021 | F2QNL8 |
| WDR45/45B | Component of the autophagy machinery that sorts cytoplasmic materials for degradation. | PI(3)P | Ji et al. 2021 | Q5MNZ6 |
| Rgd3 | Modulates and maintains Rho3 polarity during growth in budding yeast. | PI(4,5)P2 | Gingras et al. 2020 | N/A |
| PKCζ (protein kinase C zeta) | Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in the PI3K pathway. | Phosphatidic Acid, Phosphatidylserine | Velnati et al. 2020 | Q05513 |
| Gellin A & B | Central effectors of wound-induced protoplasmic gelation. | Phosphatidic Acid | Nguyen et al. 2020 | N/A |
| IFITM3 | Endosomal protein that blocks viral infection. | PI(3,4,5)P3 | Lee et al. 2020 | Q01628 |
| ERD7 | Induced due to dehydration stress in plants. | PI(4,5)P2, PIPs | Barajas-Lopez et al. 2020 | O48832 |
| PDZD8 | Contributes to endosome maturation and intracellular calcium dynamics. | PI(4)P, PS | Shirane et al. 2020 | B9EJ80 |
| PATELLIN2 | Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. | PI(4)P, PI(4,5)P2 | Montad et al. 2020 | Q56ZI2 |
| EHBP1 | An adaptor protein that regulates vesicular trafficking by recruiting Rab8 family members and EHD1/2. | PI(3)P, PI(5)P | Rai et al. 2020 | Q8NDI1 |
| RCD-1 | Regulates programmed cell death spores in the fungus Neurospora crassa. | PS, CL | Daskalov et al. 2020 | Q7S6F2 |
| LDHA | Catalyzes conversion of pyruvate to lactate. | PA | Hoshino et al. 2020 | P06151 |
| EXO70B1 | Component of an exocyst subcomplex specifically involved in autophagy-related membrane traffic. | PI(3)P, PI(5)P | Pecenkova et al. 2020 | Q9FGH9 |
| SidC | Anchors to membrane PI(4)P potentially for vacoule formation or as an adaptor. | PI(4)P | Weber et al. 2006 | Q5ZSK6 |
| PLC-d1-PH | Mediates production of the second messenger molecules DAG and IP3 | PI(4,5)P2 | Sidhu et al. 2005 | P51178 |
| p40 PX | Component of NADPH-oxidase | PI(3)P | Stahelin et al. 2003 | O43739 |
| Grp1-PH | PH domain of Grp1, a Guanine-nucleotide releasing factor | PI(3,4,5)P3 | Saxena et al. 2002 | Q15080 |
| Spo20p | Meiosis-specific subunit of the t-SNARE complex. | PA | Kassas et al 2017 | C7GLA2 |
| TRAF2 | Regulates activation of NF-kappa-B and JNK | PI(3)P | Workman et al. 2020 | Q12933 |
| ZmGLR | Role in cortical microtubule reorientation and maize leaf morphogenesis. | PIPn | Wang et al. 2019 | E9NMH5 |
| WDFY2 | Plays a role in endosomal control of AKT2 signaling. | PI(3)P | Sneeggen et al. 2019 | Q96P53 |
| Vps13B | Tethering factor in vesicle traffic between early and recycling endosomes. | PI(3)P | Koike et al. 2019 | Q80TY5 |
| VIPP1 | "Plays crucial roles in the biogenesis and repair of thylakoid membrane protein complexes" | PI(4)P | Theis et al. 2019 | Q66YD0 |
| Vav1 | Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. | PI(5)P | Rodriguez-Fdez et al. 2019 | P27870 |
| RASP2 | Plays a key role in rhoptry exocytosis. | PI(4)P, PI(4,5)P2, PA | Suarez et al. 2019 | A0A384KK73 |
| SopF | Type III secretion system effector protein. | PI(4)P, PI(3,4)P2, PI(3,4,5)P3 | Lau et al. 2019 | A0A0F7DID8 |
| SNX3 | Phosphoinositide-binding protein required for multivesicular body formation. | PI(3)P | Klose et al. 2019 | O60493 |
| RGS12 | Regulates G protein-coupled receptor signaling cascades. | PI(5)P | Schroer et al. 2019 | O08774 |
| RavD | Trafficking of Legionella-containing vacuoles. | PI(3)P | Pike et al. 2019 | A0A509GV61 |
| Psd2 | Possesses antifungal activity sensitive to inorganic cations. | PI(3)P, PI(5)P, Phosphatidylserine, Cardiolipin | Amaral et al. 2019 | P81930 |
| PLK1 | Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle. | mono-PIPs, PA | Lin et al. 2019 | P53350 |
| PKCζ | Calcium- and diacylglycerol-independent serine/threonine-protein kinase. | Sphingosine 1-phosphate, sphingosine | Kajimoto et al. 2019 | Q05513 |
| MPEG1/Perforin-2 | Perforin-like protein that functions within the phagolysosome to damage engulfed microbes. | Phosphatidylserine, Cardiolipin, PI, PI(4)P, PI(4,5)P2 | Pang et al. 2019 | Q2M385 |
| Mfn2 | Mitochondrial membrane protein with a role connecting ER membranes to mitochondria. | Phosphatidic Acid, Phosphatidylserine | Hernandez-Alvarez et al. 2019 | O95140 |
| CelTOS | Malaria parasite protein required for cell traversal in hosts. | PI(4,5)P2, PI(3,4,5)P3 | Punde et al. 2019 | A0A2R4QLJ4 |
| cGAS | Sensor of cytosolic DNA. | PI(4,5)P2 | Barnett et al. 2019 | Q8N884 |
| CKM | Catalyzes the transfer of phosphate between ATP and various phosphogens. | Phosphatidic Acid | Hoshino et al. 2019 | P07310 |
| EXO70H4 | EXO70 subunit of the exocyst complex. | Phosphatidylserine, Cardiolipin | Kubatova et al. 2019 | Q9SF51 |
| GRAMD1A | Cholesterol transfer protein. | predominantly mono-PIPs | Laraia et al. 2019 | M0R0J9 |
| Irgb6 | Involved in innate cell-autonomous resistance to intracellular pathogens. | mono-PIPs, Phosphatidylserine | Lee et al. 2019 | Q62293 |
| K-Ras4B | Binds GDP/GTP and possess intrinsic GTPase activity. | Most PIPs, Phosphatidic Acid | Cao et al. 2019 | P01116 |
| GPA5 | Plant-unique phox-homology domain-containing protein. | PI(3)P | Ren et al. 2020 | N/A |