COVID-19 Resources

COVID-19 Resources, SARS-CoV-2 Schematic - Echelon Biosciences

Tools and Reagents

Cationic Lipids: cKK-E12, ALC-0315, ALC-0159

Lipids: (PA, PE, PC), Phosphoinositides, LBPA, Sphingosine

Antibodies: PI(4)P, PI(4,5)P2, LBPA

Peptides: Spike-binding Peptide 1 (SBP1), Furin inhibitor, ACE/Angiotensin, Antimicrobial peptides

Extracellular Matrix: HA ELISA, Hyaluronidase Assay, Heparin ELISA, Inhibitors

ARDS: S1P ELISA, S1P Antibody, 4-Demethylaminosancycline (CMT-3)

Possible antimicrobial compounds: Monolaurin, Monocaprin, Tin protoporphyrin

Inhibitors: Apilimod

Lipid Binding: Lipid Conjugated Beads (pulldown assays)

Featured Articles

7-27-21 JCI Insight

COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction

7-9-21 Scientific Reports

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients

11-6-20 Journal of Biological Chemistry

Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2

7-24-20 Nature

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

7-23-20 BioRxiv Preprint

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

References

  1. Dewald Schoeman & Burtram C. Fielding, Coronavirus envelope protein: current knowledge. Virology Journal volume 16, Article number: 69 (2019)
  2. Miguel A. Martín-Acebes, Ángela Vázquez-Calvo, Flavia Caridi, Juan-Carlos Saiz and Francisco Sobrino, Lipid Involvement in Viral Infections: Present and Future Perspectives for the Design of Antiviral Strategies. Chapter, Lipid Metabolism (2013)
  3. Daniel Wrapp, Nianshuang Wang, Kizzmekia S. Corbett, Jory A. Goldsmith, Ching-Lin Hsieh, Olubukola Abiona, Barney S. Graham, Jason S. McLellan, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science Vol. 367, Issue 6483, pp. 1260-1263 (2020)
  4. Shi, Y., Wang, Y., Shao, C. et al., COVID-19 infection: the perspectives on immune responses. Cell Death & Differentiation (2020)
  5. Ankit B. Patel, MD, PhD,  Ashish Verma, MBBS, COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence? JAMA (2020)
  6. Le Blanc, I., Luyet, P., Pons, V. et al. Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol 7, 653–664 (2005)
  7. David Plotnik, Wenjin Guo, Brad Cleveland, Priska von Haller, Jimmy K. Eng, Miklos Guttman, Kelly K. Lee, James Arthos, Shiu-Lok Hu, Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7. Journal of Virology 91 (2017)
  8. Zhao, J., Tan, Y., Wang, L. et al. Serum sphingosine-1-phosphate levels and Sphingosine–1–Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study. J Transl Med 18, 156 (2020)
  9. Roy, Shreyas K.; Kubiak, Brian D.; Albert, Scott P.; Vieau, Christopher J. et al. Chemically Modified Tetracycline 3 Prevents Acute Respiratory Distress Syndrome in a Porcine Model of Sepsis + Ischemia/Reperfusion–Induced Lung Injury
    Shock 37 (4) p 424-432 (2012)
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