COVID-19 Resources

Tools and Reagents
Cationic Lipids: cKK-E12, ALC-0315, ALC-0159
Lipids: (PA, PE, PC), Phosphoinositides, LBPA, Sphingosine
Antibodies: PI(4)P, PI(4,5)P2, LBPA
Peptides: Spike-binding Peptide 1 (SBP1), Furin inhibitor, ACE/Angiotensin, Antimicrobial peptides
Extracellular Matrix: HA ELISA, Hyaluronidase Assay, Heparin ELISA, Inhibitors
ARDS: S1P ELISA, S1P Antibody, 4-Demethylaminosancycline (CMT-3)
Possible antimicrobial compounds: Monolaurin, Monocaprin, Tin protoporphyrin
Inhibitors: Apilimod
Lipid Binding: Lipid Conjugated Beads (pulldown assays)
Featured Articles
7-27-21 JCI Insight
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction
7-9-21 Scientific Reports
11-6-20 Journal of Biological Chemistry
Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2
7-24-20 Nature
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
7-23-20 BioRxiv Preprint
References
- Dewald Schoeman & Burtram C. Fielding, Coronavirus envelope protein: current knowledge. Virology Journal volume 16, Article number: 69 (2019)
- Miguel A. Martín-Acebes, Ángela Vázquez-Calvo, Flavia Caridi, Juan-Carlos Saiz and Francisco Sobrino, Lipid Involvement in Viral Infections: Present and Future Perspectives for the Design of Antiviral Strategies. Chapter, Lipid Metabolism (2013)
- Daniel Wrapp, Nianshuang Wang, Kizzmekia S. Corbett, Jory A. Goldsmith, Ching-Lin Hsieh, Olubukola Abiona, Barney S. Graham, Jason S. McLellan, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science Vol. 367, Issue 6483, pp. 1260-1263 (2020)
- Shi, Y., Wang, Y., Shao, C. et al., COVID-19 infection: the perspectives on immune responses. Cell Death & Differentiation (2020)
- Ankit B. Patel, MD, PhD, Ashish Verma, MBBS, COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence? JAMA (2020)
- Le Blanc, I., Luyet, P., Pons, V. et al. Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol 7, 653–664 (2005)
- David Plotnik, Wenjin Guo, Brad Cleveland, Priska von Haller, Jimmy K. Eng, Miklos Guttman, Kelly K. Lee, James Arthos, Shiu-Lok Hu, Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7. Journal of Virology 91 (2017)
- Zhao, J., Tan, Y., Wang, L. et al. Serum sphingosine-1-phosphate levels and Sphingosine–1–Phosphate gene polymorphisms in acute respiratory distress syndrome: a multicenter prospective study. J Transl Med 18, 156 (2020)
- Roy, Shreyas K.; Kubiak, Brian D.; Albert, Scott P.; Vieau, Christopher J. et al. Chemically Modified Tetracycline 3 Prevents Acute Respiratory Distress Syndrome in a Porcine Model of Sepsis + Ischemia/Reperfusion–Induced Lung Injury
Shock 37 (4) p 424-432 (2012)