Upcoming Conferences

** All conferences are currently planned as in-person meetings. Adjustments or cancellations due to COVID-19 will be updated where applicable.**

Annual meeting of the American Society for Biochemistry and Molecular Biology (ASBMB)

March 25-28, 2023 | Seattle, Washington, USA     EVENT WEBSITE

American Association for Cancer Research Annual Meeting

April 14-19, 2023 | Orlando, Florida     EVENT WEBSITE

2023 meeting of the International Society for Hyaluronan Sciences (ISHAS)

June 4-8, 2023 | Portland, Oregon, USA     EVENT WEBSITE

Research Society on Alcoholism (RSA) Annual Scientific Meeting June 24-28, 2023 | Bellevue, Washington     EVENT WEBSITE

Joint meeting of the American Society for Matrix Biology (ASMB), The Histochemical Society (HCS), and the American Society for Investigative Pathology (ASIP)

October 22-25, 2023 | Salt Lake City, Utah, USA     EVENT WEBSITE

American Society for Cell Biology Annual Meeting 

December 2-6, 2023 | Boston, Massachusetts, USA     EVENT WEBSITE 

Presentations

RSA 2022

Phosphatidylethanol (PEth) is an accurate long-term direct biomarker of alcohol ingestion. We set out to develop a simple 96-well assay to detect PEth from human whole blood specimens applied to dried blood spot (DBS) cards. Using ex vivo and authentic in vivo blood samples, we developed methods for PEth extraction and a competitive ELISA that could reproducibly distinguish PEth in samples representing moderate and heavy alcohol consumption with high specificity and sensitivity.  This is the first commercially available 96-well PEth ELISA.

PI3K Seminar Series 2020

Part of an ongoing virtual seminar series to address PI3K as a drug target: Class I PI3K: disease modeling and drug targeting. This presentation was an invited talk detailing methodological considerations for visualizing lipids in cells via immunostaining. 

ISHAS HA Conference 2019

Hyaluronic acid (HA) is a well-studied glycosaminoglycans (GAG) due to its involvement in a wide range of diseases and serum HA concentration is correlated to non-alcoholic fatty liver disease (NAFLD) and often used as a biomarker for liver fibrosis. Here we explore the alcohol induced HA signaling pathway by screening possible serum HA binding proteins. We found a 160 kDa serum HA binding protein was significantly reduced at 3 hours after alcohol consumption, but protein levels returned to baseline 6 hours after alcohol consumption. This result demonstrates a quick and easy method to identify HA levels and possible HA binding partners after acute alcohol ingestion.

Experimental Biology 2018 

Current methods of extracting and separating phospholipids from biological sources are known to have considerable variation which makes downstream quantification difficult. In this study, we used a PI(4)P specific ELISA to examine the possible sources of this variation including the sample, extraction procedure, and presentation of the lipids. Results using Echelon’s PI(4)P ELISA show that the assay has a low coefficient of variation if the samples and lipids are presented in a standardized manner.

FASEB 2018 #1

Lysosomal phospholipase A2 (LPLA2) is involved in both drug-induced phospholipidosis (DIPL) & drug-induced lupus (DIL), in which, tissue inflammation and organ
damage are observed. Here, we studied the charge & structure of the phospholipid substrate in relation to LPLA2 activity utilizing a self-quenched fluorogenic probe specifically designed for LPLA2 in acidic environment.

 

FASEB 2018 #2

Autoantibodies to endogenous lipids can be readily found across a variety of tissues and have been implicated in autoimmune disease(s). Diagnosing these diseases typically relies on traditional techniques, such as ELISA, which may not adequately reproduce the in vivo presentation of lipids. Here, we examined several lipids involved in antiphospholipid syndrome (APS), an autoimmune disorder, and how their detection was impacted by the method of presentation.

SLAS 2018 

Antibiotic resistance is an expanding issue worldwide and as such research into novel antibiotics remains a high priority. The synthesis of isoprenoids is vital to both bacteria and humans; however, bacteria have a distinct pathway to accomplish this, the MEP pathway. In this study, we used a combination of virtual and in vitro approaches to characterize a screen for the identification of novel MEP pathway inhibitors.

SLAS 2017 

Drug-induced phospholipidosis (DIPL) is often triggered by the intake of cationic amphiphilic drugs (CADs), in which, resulted in lipid accumulation in lysosome. In this study, we explored a high-throughput enzymatic screening method targeting the activity of lysosomal phospholipase A2 (LPLA2), one of the enzymes responsible for normal lipid turnover and metabolism, in predicting DIPL.

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