Clinical Studies of Lung Damage A biomarker is a measurable substance, usually in blood, whose presence indicates a disease, infection, …
S1P as a Biomarker of Clinical Severity in ARDS and COVID-19 SARS Read More »
Alcohol consumption is an ongoing public health issue that represents up to five percent of the global disease burden. Clinical …
Phosphatidylethanol: A biomarker of alcohol consumption Read More »
Echelon Biosciences has been making PIP Strips, a supported nitrocellulose membrane spotted with 8 phosphoinositides and 7 other biologically relevant …
Previously, we outlined the general feasibility of lipid immunostaining (immunocytochemistry, ICC and immunohistochemistry, IHC) as this technique has historically been …
Phospholipidosis (PL) is lysosomal storage disorder characterized by the excessive accumulation of intracellular phospholipids (Figure 1). The mechanism of phospholipidosis …
Drug-Induced Phospholipidosis: Best Practices and Screening Read More »
Phospholipid Enzymes in Cancer Phospholipids were once thought to be pedestrian structural components of cell membranes. Researchers have since discovered …
PI3K: Function, Signaling, and Therapeutic Avenues Read More »
Exosomes and extracellular vesicles (EVs) comprise a family of lipid enclosed particles that are released from cells. While the first observations of EVs were made in the mid 20th century, interest in these particles has exploded over the last 15 years.
Clearance of apoptotic cells via phagocytosis is the final stage of apoptosis. Efficient clearance of apoptotic cells is a critical component of maintaining homeostasis, especially in tissues with high rates of cellular turnover. While there has been much progress made in understanding the underlying mechanisms of this process, new tools are needed to advance further insights. Here, we outline the development and use of lipid microparticles that mimic cellular ‘eat me’ signals for use in the study of phagocytosis.
Methods for determining Hyaluronic Acid molecular weight Hyaluronic Acid, also known as Hyaluronan, is a natural non-sulfated glycosaminoglycan produced in …
How to Determine Hyaluronic Acid Molecular Weight Using Gel Electrophoresis Read More »
Immunostaining is a long-standing method that utilizes antibodies to label biological targets in live and fixed cells and tissues. The majority of immunostaining reported in the scientific literature is centered on proteins, but lipid immunostaining is also possible.