Phospholipidosis (PL) is lysosomal storage disorder characterized by the excessive …
Exosomes and extracellular vesicles (EVs) comprise a family of lipid enclosed particles that are released from cells. While the first observations of EVs were made in the mid 20th century, interest in these particles has exploded over the last 15 years.
Clearance of apoptotic cells via phagocytosis is the final stage of apoptosis. Efficient clearance of apoptotic cells is a critical component of maintaining homeostasis, especially in tissues with high rates of cellular turnover. While there has been much progress made in understanding the underlying mechanisms of this process, new tools are needed to advance further insights. Here, we outline the development and use of lipid microparticles that mimic cellular ‘eat me’ signals for use in the study of phagocytosis.
Immunostaining is a long-standing method that utilizes antibodies to label biological targets in live and fixed cells and tissues. The majority of immunostaining reported in the scientific literature is centered on proteins, but lipid immunostaining is also possible.