SKI-178 (SPHK1 Inhibitor)

Catalog No.:  B-0028
MW: 394.43
CAS: 1259484-97-3

SKI-178 is a selective inhibitor of sphingosine kinase 1 which is active in vitro and in vivo. SKI-178 is a competitive inhibitor of sphingosine binding to SPHK1 (Ki = 1.3 uM) and shows no inhibition of SPHK2 up to 25 uM. SKI-178 is cytotoxic to numerous cancer cell lines (MCF-7, A549, Panc-1, etc) at low to sub-micromolar concentrations.


-20 °C


1) J.A. Hengst et al. “Development of a sphingosine kinase 1 specific small-molecule inhibitor” Bioorg. Med. Chem. Lett. 2010, 20, 7498-7502. doi: 10.1016/j.bmcl.2010.10.005
2) T.E. Dick et al. “The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines” J. Pharmacol. Exp. Ther. 2015, 352, 494-508. doi: 10.1124/jpet.114.219659

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Options/Sizes Pricing
B-0028-10mg $ 89.00
B-0028-25mg $ 205.00
Additional Information:
Tech Data Sheet - B-0028

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assay and reagents for drug discovery in lipid signaling pathways