Phosphatidylinositol 3,4,5-trisphosphate diC8 (PI(3,4,5)P3 diC8)

Catalog No.:  P-3908
MW: 980.42
CAS: 163563-77-7

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.


-20 °C

Featured in Publications

1) Paternotte, N., J. Zhang, et al. (2005). "SHIP2 interaction with the cytoskeletal protein Vinexin." FEBS J 272(23): 6052-66.
2) Odriozola, L., G. Singh, et al. (2007). "Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain." J Biol Chem 282(32): 23306-15.
3) Hubbard, L. L., C. A. Wilke, et al. (2011). "PTEN Limits Alveolar Macrophage Function Against Pseudomonas aeruginosa Following Bone Marrow Transplantation." Am J Respir Cell Mol Biol 45(5): 1050-1058.

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Product Keywords: Dioctanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 C8, PI(3,4,5)P3 C8, or PIP3

Bulk discounts available, please email for information.

Options/Sizes Pricing
P-3908-100ug $ 46.00
P-3908-500ug $ 196.00
P-3908-1mg $ 365.00
Additional Information:
Tech Data Sheet - P-3908 Sodium Salt


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assay and reagents for drug discovery in lipid signaling pathways