Products

Fluorescein conjugated Anti-PI(3,4,5)P3 IgM

 
Catalog No.:  Z-G345

Description:  Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with fluorecein.
Subclass: IgM
Source: Mouse
Applications: ELISA, Immunofluorescence

Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

Protect from light. 2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

Featured in Publications

1) Vedham, V., H. Phee, et al. (2005). "Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis." Mol Cell Biol 25(10): 4211-20.
2) Gupta, S., A. R. Ramjaun, et al. (2007). "Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice." Cell 129(5): 957-68.
3) Lin, H. V., L. Plum, et al. (2010). "Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons." Diabetes 59(2): 337-346.

Related Products

Purified Anti-PtdIns(3,4,5)P3 IgM (Z-P345)
Biotinylated Anti-PtdIns(3,4,5)P3 IgM (Z-B345)
Anti-PtdIns(3,4,5)P3 IgM HRP (Z-H345)
Purified Anti-PtdIns(3,4,5)P3 IgG (Z-P345b)

Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3


Options/Sizes Pricing
Z-G345-10ug $ 207.00
Z-G345-50ug $ 393.00
Z-G345-250ug $ 1,137.00
Additional Information:
Tech Data Sheet - TDS_Z-G345_Rev5

Protocol - Protocol for immunofluorescence in chamber slides

Protocol - Protocol for frozen tissue sections


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assay and reagents for drug discovery in lipid signaling pathways