Echelon Biosciences, Inc. Product Citations

1997

Zhang, X., Loijens, J.C., Boronenkov, I.V., Parker, G.J., Norris, F.A., Chen, J., Thum, O., Prestwich, G.D., Majerus, P.W. & Anderson, R.A. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem 272, 17756-61 (1997).

1998

Banfic, H., Downes, C.P. & Rittenhouse, S.E. Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273, 11630-7 (1998).

Denisov, G., Wanaski, S., Luan, P., Glaser, M. & McLaughlin, S. Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4,5-bisphosphate: an electrostatic model and experimental results. Biophys J 74, 731-44 (1998).

Gaullier, J.M., Simonsen, A., D'Arrigo, A., Bremnes, B., Stenmark, H. & Aasland, R. FYVE fingers bind PtdIns(3)P [letter; comment]. Nature 394, 432-3 (1998).

Jenco, J.M., Rawlingson, A., Daniels, B. & Morris, A.J. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry 37, 4901-9 (1998).

Kearns, M.A., Monks, D.E., Fang, M., Rivas, M.P., Courtney, P.D., Chen, J., Prestwich, G.D., Theibert, A.B., Dewey, R.E. & Bankaitis, V.A. Novel developmentally regulated phosphoinositide binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeast. Embo J 17, 4004-17 (1998).

Patki, V., Lawe, D.C., Corvera, S., Virbasius, J.V. & Chawla, A. A functional PtdIns(3)P-binding motif [letter] [see comments]. Nature 394, 433-4 (1998).

Rao, V.D., Misra, S., Boronenkov, I.V., Anderson, R.A. & Hurley, J.H. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94, 829-39 (1998).

Tolias, K.F., Rameh, L.E., Ishihara, H., Shibasaki, Y., Chen, J., Prestwich, G.D., Cantley, L.C. & Carpenter, C.L. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5- phosphate. J Biol Chem 273, 18040-6 (1998).

Wang, P.Y., Kitchens, R.L. & Munford, R.S. Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide. J Biol Chem 273, 24309-13.(1998).

Wurmser, A.E. & Emr, S.D. Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities. Embo J 17, 4930-42 (1998).

1999

Arneson, L.S., Kunz, J., Anderson, R.A. & Traub, L.M. Coupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes. J Biol Chem 274, 17794-805 (1999).

Blader, I.J., Cope, M.J., Jackson, T.R., Profit, A.A., Greenwood, A.F., Drubin, D.G., Prestwich, G.D. & Theibert, A.B. GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Mol Biol Cell 10, 581-96 (1999).

Burden, L.M., Rao, V.D., Murray, D., Ghirlando, R., Doughman, S.D., Anderson, R.A. & Hurley, J.H. The flattened face of type II beta phosphatidylinositol phosphate kinase binds acidic phospholipid membranes. Biochemistry 38, 15141-9 (1999).

Deak, M., Casamayor, A., Currie, R.A., Downes, C.P. & Alessi, D.R. Characterisation of a plant 3-phosphoinositide-dependent protein kinase- 1 homologue which contains a pleckstrin homology domain. FEBS Lett 451, 220-6 (1999).

Dowler, S., Currie, R.A., Downes, C.P. & Alessi, D.R. DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J 342, 7-12 (1999).

Fleming, I.N., Elliott, C.M., Buchanan, F.G., Downes, C.P. & Exton, J.H. Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem 274, 12753-8. (1999).

Gaidarov, I., Krupnick, J.G., Falck, J.R., Benovic, J.L. & Keen, J.H. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. Embo J 18, 871-81 (1999).

Gaullier, J.M., Gillooly, D., Simonsen, A. & Stenmark, H. Regulation of endocytic membrane traffic by phosphatidylinositol 3- phosphate. Biochem Soc Trans 27, 666-70 (1999).

Gaullier, J.M., Simonsen, A., D'Arrigo, A., Bremnes, B. & Stenmark, H. FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate. Chem Phys Lipids 98, 87-94 (1999).

Georgescu, M.M., Kirsch, K.H., Akagi, T., Shishido, T. & Hanafusa, H. The tumor-suppressor activity of PTEN is regulated by its carboxyl- terminal region. Proc Natl Acad Sci U S A 96, 10182-7 (1999).

Jones, S.M., Klinghoffer, R., Prestwich, G.D., Toker, A. & Kazlauskas, A. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 9, 512-21. (1999).

Kutateladze, T.G., Ogburn, K.D., Watson, W.T., de Beer, T., Emr, S.D., Burd, C.G. & Overduin, M. Phosphatidylinositol 3-phosphate recognition by the FYVE domain. Mol Cell 3, 805-11 (1999).

Lee, J.O., Yang, H., Georgescu, M.M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, J.E., Pandolfi, P. & Pavletich, N.P. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99, 323-34 (1999).

Rao, V.R., Corradetti, M.N., Chen, J., Peng, J., Yuan, J., Prestwich, G.D. & Brugge, J.S. Expression cloning of protein targets for 3-phosphorylated phosphoinositides. J Biol Chem 274, 37893-900 (1999).

Rohacs, T., Chen, J., Prestwich, G.D. & Logothetis, D.E. Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem 274, 36065-72 (1999).

Sbrissa, D., Ikonomov, O.C. & Shisheva, A. PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem 274, 21589-97 (1999).

Shisheva, A., Sbrissa, D. & Ikonomov, O. Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells. Mol Cell Biol 19, 623-34 (1999).

Sims, B., Mahnke-Zizelman, D.K., Profit, A.A., Prestwich, G.D., Sabina, R.L. & Theibert, A.B. Regulation of AMP deaminase by phosphoinositides. J Biol Chem 274, 25701-7 (1999).

Thomas, C.L., Steele, J., Prestwich, G.D. & Schiavo, G. Generation of phosphatidylinositol-specific antibodies and their characterization. Biochemical Society Transactions 27, 648-651 (1999).

2000

Dowler, S., R, A.C., D, G.C., Deak, M., Kular, G., Downes, C.P. & D, R.A. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 351, 19-31 (2000).

Fleming, I.N., Gray, A. & Downes, C.P. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J 351, 173-182 (2000).

Gaullier, J.M., Ronning, E., Gillooly, D.J. & Stenmark, H. Interaction of the EEA1 FYVE finger with phosphatidylinositol 3- phosphate and early endosomes. Role of conserved residues. J Biol Chem 275, 24595-600 (2000).

Gillooly, D.J., Morrow, I.C., Lindsay, M., Gould, R., Bryant, N.J., Gaullier, J.M., Parton, R.G. & Stenmark, H. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells [In Process Citation]. Embo J 19, 4577-88 (2000).

Greenwood, J.A., Theibert, A.B., Prestwich, G.D. & Murphy-Ullrich, J.E. Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin. J Cell Biol 150, 627-42 (2000).

Han, S.Y., Kato, H., Kato, S., Suzuki, T., Shibata, H., Ishii, S., Shiiba, K., Matsuno, S., Kanamaru, R. & Ishioka, C. Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay. Cancer Res 60, 3147-51 (2000).

Hodgkin, M.N., Masson, M.R., Powner, D., Saqib, K.M., Ponting, C.P. & Wakelam, M.J. Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-biphosphate-specific PH domain. Curr Biol 10, 43-6 (2000).

Holz, R.W., Hlubek, M.D., Sorensen, S.D., Fisher, S.K., Balla, T., Ozaki, S., Prestwich, G.D., Stuenkel, E.L. & Bittner, M.A. A pleckstrin homology domain specific for phosphatidylinositol 4, 5- bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis. J Biol Chem 275, 17878-85 (2000).

Hughes, W.E., Woscholski, R., Cooke, F.T., Patrick, R.S., Dove, S.K., McDonald, N.Q. & Parker, P.J. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem 275, 801-8 (2000).

Kunz, J., Wilson, M.P., Kisseleva, M., Hurley, J.H., Majerus, P.W. & Anderson, R.A. The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 5, 1-11 (2000).

Macia, E., Paris, S. & Chabre, M. Binding of the PH and polybasic C-terminal domains of ARNO to phosphoinositides and to acidic lipids. Biochemistry 39, 5893-901 (2000).

Mehrotra, B., Myszka, D.G. & Prestwich, G.D. Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry 39, 9679-86 (2000).

Ooms, L.M., McColl, B.K., Wiradjaja, F., Wijayaratnam, A.P., Gleeson, P., Gething, M.J., Sambrook, J. & Mitchell, C.A. The yeast inositol polyphosphate 5-phosphatases inp52p and inp53p translocate to actin patches following hyperosmotic stress: mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations. Mol Cell Biol 20, 9376-90 (2000).

Ozaki, S., DeWald, D.B., Shope, J.C., Chen, J. & Prestwich, G.D. Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc Natl Acad Sci U S A 97, 11286-11291 (2000).

Razzini, G., Berrie, C.P., Vignati, S., Broggini, M., Mascetta, G., Brancaccio, A. & Falasca, M. Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines. Faseb J 14, 1179-87 (2000).

Razzini, G., Brancaccio, A., Lemmon, M.A., Guarnieri, S. & Falasca, M. The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1). J Biol Chem 275, 14873-81 (2000).

Razzini, G., Ingrosso, A., Brancaccio, A., Sciacchitano, S., Esposito, D.L. & Falasca, M. Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. Mol Endocrinol 14, 823-36 (2000).

Rickert, P., Weiner, O.D., Wang, F., Bourne, H.R. & Servant, G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol 10, 466-73 (2000).

Sbrissa, D., Ikonomov, O.C. & Shisheva, A. PIKfyve lipid kinase is a protein kinase: downregulation of 5'- phosphoinositide product formation by autophosphorylation [In Process Citation]. Biochemistry 39, 15980-9 (2000).

Selengut, J.D. & Levine, R.L. MDP-1: A novel eukaryotic magnesium-dependent phosphatase. Biochemistry 39, 8315-24. (2000).

Takeuchi, H., Oike, M., Paterson, H.F., Allen, V., Kanematsu, T., Ito, Y., Erneux, C., Katan, M. & Hirata, M. Inhibition of Ca2+ signalling by p130, a phospholipase-C-related catalytically inactive protein: critical role of the p130 pleckstrin homology domain. Biochem J 349, 357-368 (2000).

Taylor, G.S., Maehama, T. & Dixon, J.E. Inaugural article: myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A 97, 8910-5 (2000).

2001

Barylko, B., Gerber, S.H., Binns, D.D., Grichine, N., Khvotchev, M., Sudhof, T.C. & Albanesi, J.P. A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans. J Biol Chem 276, 7705-7708. (2001).

Bravo, J., Karathanassis, D., Pacold, C.M., Pacold, M.E., Ellson, C.D., Anderson, K.E., Butler, P.J., Lavenir, I., Perisic, O., Hawkins, P.T., Stephens, L. & Williams, R.L. The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell 8, 829-39. (2001).

Caffrey, J.J., Darden, T., Wenk, M.R. & Shears, S.B. Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6- pentakisphosphate 3-phosphatase activity. FEBS Lett 499, 6-10. (2001).

Cheever, M.L., Sato, T.K., de Beer, T., Kutateladze, T.G., Emr, S.D. & Overduin, M. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 3, 613-8. (2001).

Chellaiah, M.A., Biswas, R.S., Yuen, D., Alvarez, U.M. & Hruska, K.A. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem 276, 47434-44. (2001).

Clarke, J.H., Letcher, A.J., D'Santos C, S., Halstead, J.R., Irvine, R.F. & Divecha, N. Inositol lipids are regulated during cell cycle progression in the nuclei of murine erythroleukaemia cells. Biochem J 357, 905-10. (2001).

Corvera, S. Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs. Traffic 2, 859-66. (2001).

Elge, S., Brearley, C., Xia, H.J., Kehr, J., Xue, H.W. & Mueller-Roeber, B. An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors. Plant J 26, 561-71. (2001).

Feng, L., Mejillano, M., Yin, H.L., Chen, J. & Prestwich, G.D. Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Biochemistry 40, 904-13 (2001).

Huang, Z., Guo, X.X., Chen, S.X., Alvarez, K.M., Bell, M.W. & Anderson, R.E. Regulation of Type II Phosphatidylinositol Phosphate Kinase by Tyrosine Phosphorylation in Bovine Rod Outer Segments. Biochemistry 40, 4550-4559. (2001).

Jones, S.M. & Kazlauskas, A. Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol 3, 165-72 (2001).

Kutateladze, T. & Overduin, M. Structural Mechanism of Endosome Docking by the FYVE Domain. Science 291, 1793-1796. (2001).

Marcus, S.L., Wenk, M.R., Steele-Mortimer, O. & Finlay, B.B. A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation. FEBS Lett 494, 201-7. (2001).

Mari, M., Macia, E., Le Marchand-Brustel, Y. & Cormont, M. Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. J Biol Chem 276, 42501-8. (2001).

Misra, S., Miller, G.J. & Hurley, J.H. Recognizing phosphatidylinositol 3-phosphate. Cell 107, 559-62. (2001).

Osborne, S.L., Thomas, C.L., Gschmeissner, S. & Schiavo, G. Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing. J Cell Sci 114, 2501-11. (2001).

Pattni, K., Jepson, M., Stenmark, H. & Banting, G. A PtdIns(3)P-specific probe cycles on and off host cell membranes during Salmonella invasion of mammalian cells. Curr Biol 11, 1636-42. (2001).

Rajala, R.V. & Anderson, R.E. Interaction of the insulin receptor beta-subunit with phosphatidylinositol 3-kinase in bovine ROS. Invest Ophthalmol Vis Sci 42, 3110-7 (2001).

Russo, C., Gao, Y., Mancini, P., Vanni, C., Porotto, M., Falasca, M., Torrisi, M.R., Zheng, Y. & Eva, A. Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain. J Biol Chem 276, 19524-31. (2001).

Saito, K., Scharenberg, A.M. & Kinet, J.P. Interaction between the Btk PH Domain and Phosphatidylinositol-3,4,5- trisphosphate Directly Regulates Btk. J Biol Chem 276, 16201-6. (2001).

Sankaran, V.G., Klein, D.E., Sachdeva, M.M. & Lemmon, M.A. High-affinity binding of a fyve domain to phosphatidylinositol 3- phosphate requires intact phospholipid but not fyve domain oligomerization. Biochemistry 40, 8581-7. (2001).

Santagata, S., Boggon, T.J., Baird, C.L., Gomez, C.A., Zhao, J., Shan, W.S., Myszka, D.G. & Shapiro, L. G-protein signaling through tubby proteins. Science 292, 2041-50. (2001).

Schwartzbauer, G. & Robbins, J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem 276, 35786-93. (2001).

Shisheva, A., Rusin, B., Ikonomov, O.C., DeMarco, C. & Sbrissa, D. Localization and insulin-regulated relocation of phosphoinositide 5- kinase PIKfyve in 3T3-L1 adipocytes. J Biol Chem 276, 11859-69. (2001).

Sindic, A., Aleksandrova, A., Fields, A.P., Volinia, S. & Banfic, H. Presence and Activation of Nuclear Phosphoinositide 3-Kinase C2beta during Compensatory Liver Growth. J Biol Chem 276, 17754-17761. (2001).

Snyder, J.T., Rossman, K.L., Baumeister, M.A., Pruitt, W.M., Siderovski, D.P., Der, C.J., Lemmon, M.A. & Sondek, J. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. J Biol Chem 276, 45868-75. (2001).

Song, X., Xu, W., Zhang, A., Huang, G., Liang, X., Virbasius, J.V., Czech, M.P. & Zhou, G.W. Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry 40, 8940-4. (2001).

Taylor, G.S. & Dixon, J.E. An assay for phosphoinositide phosphatases utilizing fluorescent substrates. Anal Biochem 295, 122-6. (2001).

Thomas, C.C., Dowler, S., Deak, M., Alessi, D.R. & Van Aalten, D.M. Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity. Biochem J 358, 287-94. (2001).

Thorner, J.W. Greasing the wheels of secretory transport. Nat Cell Biol 3, E196-8. (2001).

Virbasius, J.V., Song, X., Pomerleau, D.P., Zhan, Y., Zhou, G.W. & Czech, M.P. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A 98, 12908-13. (2001).

Wagner, M.L. & Tamm, L.K. Reconstituted syntaxin1a/SNAP25 interacts with negatively charged lipids as measured by lateral diffusion in planar supported bilayers. Biophys J 81, 266-75 (2001).

Wang, J.A., Anna; Hangyaw-Mihalyne, Gyongyi; McLaughlin, Stuart. The Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Binds Strongly to Phosphatidylinositol 4,5-Bisphosphate. J Biol Chem 276, 5012-5019 (2001).

Westergren, T., Dove, S.K., Sommarin, M. & Pical, C. AtPIP5K1, an Arabidopsis thaliana phosphatidylinositol phosphate kinase, synthesizes PtdIns(3,4)P(2) and PtdIns(4,5)P(2) in vitro and is inhibited by phosphorylation. Biochem J 359, 583-9. (2001).

Wilkinson, S. ACS names new editor for JOC - C. Dale Poulter will step up at the Journal of Organic Chemistry. in C & E News Vol. 79 12 (2001).

Wu, Y., Dowbenko, D., Pisabarro, M.T., Dillard-Telm, L., Koeppen, H. & Lasky, L.A. Pten 2, a golgi-associated testis-specific homologue of the pten tumor suppressor lipid phosphatase. J Biol Chem 276, 21745-53. (2001).

Xu, J., Liu, D., Gill, G. & Songyang, Z. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol 154, 699-705. (2001).

Yoshimura, K., Takeuchi, H., Sato, O., Hidaka, K., Doira, N., Terunuma, M., Harada, K., Ogawa, Y., Ito, Y., Kanematsu, T. & Hirata, M. Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. J Biol Chem 276, 17908-13 (2001).

Yu, J.W. & Lemmon, M.A. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem 276, 44179-84. (2001).

Zheng, B., Ma, Y.C., Ostrom, R.S., Lavoie, C., Gill, G.N., Insel, P.A., Huang, X.Y. & Farquhar, M.G. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science 294, 1939-42. (2001).

Zhu, H., Bilgin, M., Bangham, R., Hall, D., Casamayor, A., Bertone, P., Lan, N., Jansen, R., Bidlingmaier, S., Houfek, T., Mitchell, T., Miller, P., Dean, R.A., Gerstein, M. & Snyder, M. Global analysis of protein activities using proteome chips. Science 293, 2101-5. (2001).

2002

Adam, P., Hecht, S., Eisenreich, W., Kaiser, J., Grawert, T., Arigoni, D., Bacher, A. & Rohdich, F. Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase. Proc Natl Acad Sci U S A 99, 12108-13 (2002).

Adey, N.B., Lei, M., Howard, M.T., Jensen, J.D., Mayo, D.A., Butel, D.L., Coffin, S.C., Moyer, T.C., Slade, D.E., Spute, M.K., Hancock, A.M., Eisenhoffer, G.T., Dalley, B.K. & McNeely, M.R. Gains in sensitivity with a device that mixes microarray hybridization solution in a 25-microm-thick chamber. Anal Chem 74, 6413-7 (2002).

Bailey, A.M., Mahapatra, S., Brennan, P.J. & Crick, D.C. Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Glycobiology 12, 813-20 (2002).

Balla, A., Tuymetova, G., Barshishat, M., Geiszt, M. & Balla, T. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J Biol Chem 277, 20041-50. (2002).

Buj-Bello, A., Furling, D., Tronchere, H., Laporte, J., Lerouge, T., Butler-Browne, G.S. & Mandel, J.L. Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells. Hum Mol Genet 11, 2297-307 (2002).

Burda, P., Padilla, S.M., Sarkar, S. & Emr, S.D. Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115, 3889-900 (2002).

Burke, C. & Croteau, R. Geranyl diphosphate synthase from Abies grandis: cDNA isolation, functional expression, and characterization. Arch Biochem Biophys 405, 130-6. (2002).

Burke, C. & Croteau, R. Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate. J Biol Chem 277, 3141-9 (2002).

Chen, R., Kang, V.H., Chen, J., Shope, J.C., Torabinejad, J., DeWald, D.B. & Prestwich, G.D. A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J Histochem Cytochem 50, 697-708. (2002).

Coppolino, M.G., Dierckman, R., Loijens, J., Collins, R.F., Pouladi, M., Jongstra-Bilen, J., Schreiber, A.D., Trimble, W.S., Anderson, R. & Grinstein, S. Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem 277, 43849-57. (2002).

Crottet, P., Meyer, D.M., Rohrer, J. & Spiess, M. ARF1.GTP, tyrosine-based signals, and phosphatidylinositol 4,5- bisphosphate constitute a minimal machinery to recruit the AP-1 clathrin adaptor to membranes. Mol Biol Cell 13, 3672-82. (2002).

DeWald, D.B. Phosphoinositide signaling: vac to the future in fab1 kinase regulation. Curr Biol 12, R491-2. (2002).

Dowler, S., Kular, G. & Alessi, D.R. Protein lipid overlay assay. Sci STKE 2002, L6. (2002).

Ershov, Y.V., Gantt, R.R., Cunningham Jr, F.X., Jr. & Gantt, E. Isoprenoid biosynthesis in Synechocystis sp. strain PCC6803 is stimulated by compounds of the pentose phosphate cycle but not by pyruvate or deoxyxylulose-5-phosphate. J Bacteriol 184, 5045-51. (2002).

Field, S.J., Lamia, K.A., Rameh, L.E. & Cantley, L.C. Lipid research picks up speed on the slopes of Taos. Dev Cell 2, 407-10 (2002).

Grishanin, R.N., Klenchin, V.A., Loyet, K.M., Kowalchyk, J.A., Ann, K. & Martin, T.F. Membrane association domains in Ca2+-dependent activator protein for secretion mediate plasma membrane and dense-core vesicle binding required for Ca2+-dependent exocytosis. J Biol Chem 277, 22025-34. (2002).

Guttman, J.A., Janmey, P. & Vogl, A.W. Gelsolin--evidence for a role in turnover of junction-related actin filaments in Sertoli cells. J Cell Sci 115, 499-505 (2002).

Hairfield, M.L., Westwater, C. & Dolan, J.W. Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans. Microbiology 148, 1737-46 (2002).

Hayashi, S., Okada, T., Igarashi, N., Fujita, T., Jahangeer, S. & Nakamura, S. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J Biol Chem 277, 33319-24. (2002).

Heras, B. & Drobak, B.K. PARF-1: an Arabidopsis thaliana FYVE-domain protein displaying a novel eukaryotic domain structure and phosphoinositide affinity. J Exp Bot 53, 565-7 (2002).

Hinchliffe, K. A., M. L. Giudici, et al. (2002). "Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms." Biochem J 363(Pt 3): 563-70.

Ikonomov, O.C., Sbrissa, D., Mlak, K., Kanzaki, M., Pessin, J. & Shisheva, A. Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity. J Biol Chem 277, 9206-11. (2002).

Ishii, M., Inanobe, A. & Kurachi, Y. PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. Proc Natl Acad Sci U S A 99, 4325-30. (2002).

Kalthoff, C., Groos, S., Kohl, R., Mahrhold, S. & Ungewickell, E.J. Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Mol Biol Cell 13, 4060-73 (2002).

Karathanassis, D., Stahelin, R.V., Bravo, J., Perisic, O., Pacold, C.M., Cho, W. & Williams, R.L. Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4- bisphosphate and phosphatidic acid is masked by an intramolecular interaction. Embo J 21, 5057-68. (2002).

Kim, S.A., Taylor, G.S., Torgersen, K.M. & Dixon, J.E. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem 277, 4526-31. (2002).

Klockow, B., Tichelaar, W., Madden, D.R., Niemann, H.H., Akiba, T., Hirose, K. & Manstein, D.J. The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes. Embo J 21, 240-50 (2002).

Koppisch, A.T. & Poulter, C.D. Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol and 2-C-methyl- D-erythritol-4-phosphate. J Org Chem 67, 5416-8. (2002).

Kruger, J.M., Fukushima, T., Cherepanov, V., Borregaard, N., Loeve, C., Shek, C., Sharma, K., Tanswell, A.K., Chow, C.W. & Downey, G.P. Protein-tyrosine phosphatase MEG2 is expressed by human neutrophils. Localization to the phagosome and activation by polyphosphoinositides. J Biol Chem 277, 2620-8. (2002).

Kunz, J., Fuelling, A., Kolbe, L. & Anderson, R.A. Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J Biol Chem 277, 5611-9. (2002).

Lee, E., Marcucci, M., Daniell, L., Pypaert, M., Weisz, O.A., Ochoa, G.C., Farsad, K., Wenk, M.R. & De Camilli, P. Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science 297, 1193-6. (2002).

Li, X., Rivas, M.P., Fang, M., Marchena, J., Mehrotra, B., Chaudhary, A., Feng, L., Prestwich, G.D. & Bankaitis, V.A. Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol 157, 63-77 (2002).

Liu, X.H. & Prestwich, G.D. Didehydrogeranylgeranyl (Delta Delta GG): a fluorescent probe for protein prenylation. J Am Chem Soc 124, 20-1. (2002).

Martin, D., Tholl, D., Gershenzon, J. & Bohlmann, J. Methyl jasmonate induces traumatic resin ducts, terpenoid resin biosynthesis, and terpenoid accumulation in developing xylem of Norway spruce stems. Plant Physiol 129, 1003-18 (2002).

Mishra, S.K., Keyel, P.A., Hawryluk, M.J., Agostinelli, N.R., Watkins, S.C. & Traub, L.M. Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. Embo J 21, 4915-26 (2002).

Naga Prasad, S.V., Laporte, S.A., Chamberlain, D., Caron, M.G., Barak, L. & Rockman, H.A. Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol 158, 563-75 (2002).

Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. & Payrastre, B. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. Embo J 21, 5069-78. (2002).

Perez, O.D., Kinoshita, S., Hitoshi, Y., Payan, D.G., Kitamura, T., Nolan, G.P. and Lorens, J.B. Activation of the PKB/AKT pathway by ICAM-2. Immunity 16, 51-65 (2002).

Prestwich, G.D., Chen, R., Feng, L., Ozaki, S., Ferguson, C.G., Drees, B.E., Neklason, D.A., Mostert, M.J., Porter-Gill, P.A., Kang, V.H., Shope, J.C., Neilsen, P.O. & Dewald, D.B. In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul 42, 19-38 (2002).

Rajala, R.V., McClellan, M.E., Ash, J.D. & Anderson, R.E. In vivo regulation of phosphoinositide 3-kinase in retina through light- induced tyrosine phosphorylation of the insulin receptor beta-subunit. J Biol Chem 277, 43319-26. (2002).

Rauch, M.E., Ferguson, C.G., Prestwich, G.D. & Cafiso, D.S. Myristoylated alanine-rich C kinase substrate (MARCKS) sequesters spin- labeled phosphatidylinositol 4,5-bisphosphate in lipid bilayers. J Biol Chem 277, 14068-76. (2002).

Rohacs, T., Lopes, C., Mirshahi, T., Jin, T., Zhang, H. & Logothetis, D.E. Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods Enzymol 345, 71-92 (2002).

Rohdich, F., Hecht, S., Gartner, K., Adam, P., Krieger, C., Amslinger, S., Arigoni, D., Bacher, A. & Eisenreich, W. Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. Proc Natl Acad Sci U S A 99, 1158-63. (2002).

Runnels, L.W., Yue, L. & Clapham, D.E. The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol 4, 329-36 (2002). Rzepecki, P.W. & Prestwich, G.D. Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP(2)). J Org Chem 67, 5454-60. (2002).

Saxena, A., Morozov, P., Frank, D., Musalo, R., Lemmon, M.A., Skolnik, E.Y. & Tycko, B. Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1. J Biol Chem 277, 49935-44. (2002).

Sbrissa, D., Ikonomov, O.C., Deeb, R. & Shisheva, A. Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. J Biol Chem 277, 47276-84. (2002).

Sbrissa, D., Ikonomov, O.C. & Shisheva, A. Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization. J Biol Chem 277, 6073-9. (2002).

Scheid, M.P., Huber, M., Damen, J.E., Hughes, M., Kang, V., Neilsen, P., Prestwich, G.D., Krystal, G. & Duronio, V. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice. J Biol Chem 277, 9027-35. (2002).

Shen, T.L., Han, D.C. & Guan, J.L. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. J Biol Chem 277, 29069-77. (2002).

Terebiznik, M.R., Vieira, O.V., Marcus, S.L., Slade, A., Yip, C.M., Trimble, W.S., Meyer, T., Finlay, B.B. & Grinstein, S. Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella. Nat Cell Biol 4, 766-73. (2002).

Thapar, R., Karnoub, A.E. & Campbell, S.L. Structural and biophysical insights into the role of the insert region in Rac1 function. Biochemistry 41, 3875-83. (2002).

van Rheenen, J. & Jalink, K. Agonist-induced PIP(2) hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol Biol Cell 13, 3257-67. (2002).

Varnai, P., Lin, X., Lee, S.B., Tuymetova, G., Bondeva, T., Spat, A., Rhee, S.G., Hajnoczky, G. & Balla, T. Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130. J Biol Chem 277, 27412-22. (2002).

Wang, F., Herzmark, P., Weiner, O.D., Srinivasan, S., Servant, G. & Bourne, H.R. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 4, 513-8 (2002).

Weiner, O.D., Neilsen, P.O., Prestwich, G.D., Kirschner, M.W., Cantley, L.C. & Bourne, H.R. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4, 509-13. (2002).

Whitley, P., Gibbard, A.M., Koumanov, F., Oldfield, S., Kilgour, E.E., Prestwich, G.D. & Holman, G.D. Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Eur J Cell Biol 81, 222-30. (2002).

Zhan, Y., Virbasius, J.V., Song, X., Pomerleau, D.P. & Zhou, G.W. The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem 277, 4512-8. (2002).

Zhong, Q., Lazar, C.S., Tronchere, H., Sato, T., Meerloo, T., Yeo, M., Songyang, Z., Emr, S.D. & Gill, G.N. Endosomal localization and function of sorting nexin 1. Proc Natl Acad Sci U S A 99, 6767-72 (2002).

Zimmermann, P., Meerschaert, K., Reekmans, G., Leenaerts, I., Small, J.V., Vandekerckhove, J., David, G. & Gettemans, J. PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Mol Cell 9, 1215-25. (2002).

2003

Abram, C.L., Seals, D.F., Pass, I., Salinsky, D., Maurer, L., Roth, T.M. & Courtneidge, S.A. The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells. J Biol Chem 278, 16844-51. (2003).

Aguilar, R.C., Watson, H.A. & Wendland, B. The yeast Epsin Ent1 is recruited to membranes through multiple independent interactions. J Biol Chem 278, 10737-43. (2003).

Anzelon, A.N., Wu, H. & Rickert, R.C. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4, 287-94 (2003).

Begley, M.J., Taylor, G.S., Kim, S.A., Veine, D.M., Dixon, J.E. & Stuckey, J.A. Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol Cell 12, 1391-402 (2003).

Berger, P., C. Schaffitzel, et al. (2003). "Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module." Proc Natl Acad Sci U S A 100(21): 12177-82.

Bompard, G., Martin, M., Roy, C., Vignon, F. & Freiss, G. Membrane targeting of protein tyrosine phosphatase PTPL1 through its FERM domain via binding to phosphatidylinositol 4,5-biphosphate. J Cell Sci 116, 2519-30 (2003).

Campbell, R.B., Liu, F. & Ross, A.H. Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 278, 33617-20 (2003).

Casamayor, A. & Snyder, M. Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. Mol Cell Biol 23, 2762-77 (2003).

Chen, F., Tholl, D., D'Auria, J.C., Farooq, A., Pichersky, E. & Gershenzon, J. Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers. Plant Cell 15, 481-94 (2003).

Clarke, J.H. Lipid signalling: picking out the PIPs. Curr Biol 13, R815-7 (2003).

Corbalan-Garcia, S., Garcia-Garcia, J., Rodriguez-Alfaro, J.A. & Gomez-Fernandez, J.C. A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha. J Biol Chem 278, 4972-80. (2003).

Das, S., Dixon, J.E. and Cho, W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A 100, 7491-6 (2003).

Drees, B.E., Weipert, A., Hudson, H., Ferguson, C.G., Chakravarty, L. & Prestwich, G.D. Competitive fluorescence polarization assays for the detection of phosphoinositide kinase and phosphatase activity. Comb Chem High Throughput Screen 6, 321-30. (2003).

Du, G., Altshuller, Y.M., Vitale, N., Huang, P., Chasserot-Golaz, S., Morris, A.J., Bader, M.F. & Frohman, M.A. Regulation of phospholipase D1 subcellular cycling through coordination of multiple membrane association motifs. J Cell Biol 162, 305-15 (2003).

Dudareva, N., Martin, D., Kish, C.M., Kolosova, N., Gorenstein, N., Faldt, J., Miller, B. & Bohlmann, J. (E)-beta-ocimene and myrcene synthase genes of floral scent biosynthesis in snapdragon: function and expression of three terpene synthase genes of a new terpene synthase subfamily. Plant Cell 15, 1227-41 (2003).

Feng, L., Mills, G.B., & Prestwich, G.D. Modulators of Lysophosphatidic Acid Signaling. Expert Opinion on Therapeutic Patents 13, 1619-1634 (2003).

Friant, S., E. I. Pecheur, et al. (2003). "Ent3p Is a PtdIns(3,5)P2 effector required for protein sorting to the multivesicular body." Dev Cell 5(3): 499-511.

Fraley, T.S., Tran, T.C., Corgan, A.M., Nash, C.A., Hao, J., Critchley, D.R. & Greenwood, J.A. Phosphoinositide binding inhibits alpha -actinin bundling activity. J Biol Chem 24, 24 (2003).

Fuentes, E.J., Karnoub, A.E., Booden, M.A., Der, C.J. & Campbell, S.L. Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation. J Biol Chem 278, 21188-96 (2003).

Gottlin, E.B., Benson, R.E., Conary, S., Antonio, B., Duke, K., Payne, E.S., Ashraf, S.S. & Christensen, D.J. High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition. J Biomol Screen 8, 332-9 (2003).

Gozani, O., Karuman, P., Jones, D.R., Ivanov, D., Cha, J., Lugovskoy, A.A., Baird, C.L., Zhu, H., Field, S.J., Lessnick, S.L., Villasenor, J., Mehrotra, B., Chen, J., Rao, V.R., Brugge, J.S., Ferguson, C.G., Payrastre, B., Myszka, D.G., Cantley, L.C., Wagner, G., Divecha, N., Prestwich, G.D. & Yuan, J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114, 99-111 (2003).

Gray, A., Olsson, H., Batty, I.H., Priganica, L. & Peter Downes, C. Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts. Anal Biochem 313, 234-45. (2003).

Guo, J., Wenk, M.R., Pellegrini, L., Onofri, F., Benfenati, F. & De Camilli, P. Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles. Proc Natl Acad Sci U S A 100, 3995-4000. (2003).

Gupta, S., Fanzo, J.C., Hu, C., Cox, D., Jang, S.Y., Lee, A.E., Greenberg, S. & Pernis, A.B. T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse. J Biol Chem 278, 43541-9 (2003).

Hama, H., Torabinejad, J., Prestwich, G.D., & DeWald, D.B. Measurement and Immunofluorescence of Cellular Phosphoinositides. Methods in Molecular Biology (2003, in press).

Hanada, K., Kumagai, K., Yasuda, S., Miura, Y., Kawano, M., Fukasawa, M. & Nishijima, M. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803-9 (2003).

Hanson, B.J. & Hong, W. Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments. J Biol Chem 278, 34617-30 (2003).

Hilpela, P., Oberbanscheidt, P., Hahne, P., Hund, M., Kalhammer, G., Small, J.V. & Bahler, M. SWAP-70 identifies a transitional subset of actin filaments in motile cells. Mol Biol Cell 14, 3242-53 (2003).

Hirst, J., Motley, A., Harasaki, K., Peak Chew, S.Y. & Robinson, M.S. EpsinR: an ENTH domain-containing protein that interacts with AP-1. Mol Biol Cell 14, 625-41 (2003).

Holstein, S.A., Wohlford-Lenane, C.L., Wiemer, D.F. & Hohl, R.J. Isoprenoid pyrophosphate analogues regulate expression of Ras-related proteins. Biochemistry 42, 4384-91. (2003).

Kruljac-Letunic, A., Moelleken, J., Kallin, A., Wieland, F. & Blaukat, A. The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J Biol Chem 278, 29560-70 (2003).

Larsen, M., Hoffman, M.P., Sakai, T., Neibaur, J.C., Mitchell, J.M. & Yamada, K.M. Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol 255, 178-91. (2003).

Lee, S.J., Xu, H., Kang, L.W., Amzel, L.M. & Montell, C. Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39, 121-32 (2003).

Liu, D. and E. R. Liman (2003). "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5." Proc Natl Acad Sci U S A 100(25): 15160-5.

Lu, Y., Yu, Q., Liu, J.H., Zhang, J., Wang, H., Koul, D., McMurray, J.S., Fang, X., Yung, W.K., Siminovitch, K.A. & Mills, G.B. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 278, 40057-66 (2003).

Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R.C. & Falasca, M. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. Embo J 22, 4178-89 (2003).

Maffucci, T., Razzini, G., Ingrosso, A., Chen, H., Iacobelli, S., Sciacchitano, S., Quon, M.J. & Falasca, M. Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3. Mol Endocrinol 17, 1568-79 (2003).

Martin, D.M., Gershenzon, J. & Bohlmann, J. Induction of volatile terpene biosynthesis and diurnal emission by methyl jasmonate in foliage of Norway spruce. Plant Physiol 132, 1586-99 (2003).

McKay, S.A., Hunter, W.L., Godard, K.A., Wang, S.X., Martin, D.M., Bohlmann, J. & Plant, A.L. Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce. Plant Physiol 133, 368-78 (2003).

Merlot, S., Meili, R., Pagliarini, D.J., Maehama, T., Dixon, J.E. & Firtel, R.A. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem 278, 39866-73 (2003).

Mills, I.G., Praefcke, G.J., Vallis, Y., Peter, B.J., Olesen, L.E., Gallop, J.L., Butler, P.J., Evans, P.R. & McMahon, H.T. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J Cell Biol 160, 213-22 (2003).

Niswender, K.D., Gallis, B., Blevins, J.E., Corson, M.A., Schwartz, M.W. & Baskin, D.G. Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin. J Histochem Cytochem 51, 275-83. (2003).

Niswender, K.D., Morrison, C.D., Clegg, D.J., Olson, R., Baskin, D.G., Myers, M.G., Jr., Seeley, R.J. & Schwartz, M.W. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 52, 227-31. (2003).

Oganesian, A., Poot, M., Daum, G., Coats, S.A., Wright, M.B., Seifert, R.A. & Bowen-Pope, D.F. Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proc Natl Acad Sci U S A 100, 7563-8 (2003).

Rohacs, T., Lopes, C.M., Jin, T., Ramdya, P.P., Molnar, Z. & Logothetis, D.E. Specificity of activation by phosphoinositides determines lipid regulation of Kir channels. Proc Natl Acad Sci U S A 100, 745-50 (2003).

Rohde, H.M., Cheong, F.Y., Konrad, G., Paiha, K., Mayinger, P. & Boehmelt, G. The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. J Biol Chem 278, 52689-99 (2003).

Rossman, K.L., Cheng, L., Mahon, G.M., Rojas, R.J., Snyder, J.T., Whitehead, I.P. & Sondek, J. Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J Biol Chem 278, 18393-400. (2003).

Sato, M., Ueda, Y., Takagi, T. & Umezawa, Y. Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis. Nat Cell Biol 5, 1016-22 (2003).

Schaletzky, J., Dove, S.K., Short, B., Lorenzo, O., Clague, M.J. & Barr, F.A. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. Curr Biol 13, 504-9. (2003).

Shinoda, T. & Itoyama, K. Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis. Proc Natl Acad Sci U S A 100, 11986-91 (2003).

Six, D.A. & Dennis, E.A. Essential Ca2+-independent role of the group IVA cytosolic phospholipase A2 C2 domain for interfacial activity. J Biol Chem 278, 23842-23850 (2003).

Smyth, S.S., Sciorra, V.A., Sigal, Y.J., Pamuklar, Z., Wang, Z., Xu, Y., Prestwich, G.D. & Morris, A.J. Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J Biol Chem 278, 43214-23 (2003).

Srinivasan, S., Wang, F., Glavas, S., Ott, A., Hofmann, F., Aktories, K., Kalman, D. & Bourne, H.R. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160, 375-85 (2003).

Tabellini, G., Bortul, R., Santi, S., Riccio, M., Baldini, G., Cappellini, A., Billi, A.M., Berezney, R., Ruggeri, A., Cocco, L. & Martelli, A.M. Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus. Exp Cell Res 287, 143-54 (2003).

Takano, N., Owada, Y., Suzuki, R., Sakagami, H., Shimosegawa, T. & Kondo, H. Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs. J Neurochem 84, 829-39 (2003).

Wang, Q., Xie, Y., Du, Q.S., Wu, X.J., Feng, X., Mei, L., McDonald, J.M. & Xiong, W.C. Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol 160, 565-75 (2003).

Wang, Y.J., Wang, J., Sun, H.Q., Martinez, M., Sun, Y.X., Macia, E., Kirchhausen, T., Albanesi, J.P., Roth, M.G. & Yin, H.L. Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 114, 299-310 (2003).

Ward, D.M., Shiflett, S.L., Huynh, D., Vaughn, M.B., Prestwich, G. & Kaplan, J. Use of Expression Constructs to Dissect the Functional Domains of the CHS/Beige Protein: Identification of Multiple Phenotypes. Traffic 4, 403-15. (2003).

Whitley, P., Reaves, B.J., Hashimoto, M., Riley, A.M., Potter, B.V. & Holman, G.D. Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization. J Biol Chem 278, 38786-95 (2003).

Wouters, J., Oudjama, Y., Ghosh, S., Stalon, V., Droogmans, L. & Oldfield, E. Structure and mechanism of action of isopentenylpyrophosphate- dimethylallylpyrophosphate isomerase. J Am Chem Soc 125, 3198-9. (2003).

Yun, M., Keshvara, L., Park, C.G., Zhang, Y.M., Dickerson, J.B., Zheng, J., Rock, C.O., Curran, T. & Park, H.W. Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem 278, 36572-81 (2003).

Zhou, C.Z., de La Sierra-Gallay, I.L., Quevillon-Cheruel, S., Collinet, B., Minard, P., Blondeau, K., Henckes, G., Aufrere, R., Leulliot, N., Graille, M., Sorel, I., Savarin, P., de la Torre, F., Poupon, A., Janin, J. & van Tilbeurgh, H. Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. J Biol Chem 278, 50371-6 (2003).

2004

Ahn, J.-Y., Rong, R., Liu, X. and Ye, K. PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J. sj.emboj.7600392 (2004).

Arimura, G.-i., Ozawa, R., Kugimiya, S., Takabayashi, J. and Bohlmann, J. Herbivore-Induced Defense Response in a Model Legume. Two-Spotted Spider Mites Induce Emission of (E)-{beta}-Ocimene and Transcript Accumulation of (E)-{beta}-Ocimene Synthase in Lotus japonicus. Plant Physiology 135, 1976-1983 (2004).

Bagga, S., Price, K.S., Lin, D.A., Friend, D.S., Austen, K.F. and Boyce, J.A. Lysophosphatidic acid accelerates the development of human mast cells. Blood 2004-03-1166 (2004).

Buurman, E. T., A. E. Blodgett, et al. (2004). "Pyridines and pyrimidines mediating activity against an efflux-negative strain of Candida albicans through putative inhibition of lanosterol demethylase." Antimicrob Agents Chemother 48(1): 313-8.

CAO, X., KAMBE, F., MOELLER, L.C., REFETOFF, S. and SEO, H. Thyroid hormone induces rapid activation of Akt/PKB-mTOR-p70S6K cascade through PI3K in human fibroblasts. Mol. Endocrinol. me.2004-0093 (2004).

Chang, J.D., Field, S.J., Rameh, L.E., Carpenter, C.L. & Cantley, L.C. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem 279, 11672-9 (2004).

Chen, F., Ro, D.-K., Petri, J., Gershenzon, J., Bohlmann, J., Pichersky, E. and Tholl, D. Characterization of a Root-Specific Arabidopsis Terpene Synthase Responsible for the Formation of the Volatile Monoterpene 1,8-Cineole. Plant Physiology 135, 1956-1966 (2004).

Chen, G., Raman, P., Bhonagiri, P., Strawbridge, A.B., Pattar, G.R. and Elmendorf, J.S. Protective Effect of Phosphatidylinositol 4,5-Bisphosphate against Cortical Filamentous Actin Loss and Insulin Resistance Induced by Sustained Exposure of 3T3-L1 Adipocytes to Insulin. J. Biol. Chem. 279, 39705-39709 (2004).

Cheng, G. & Lambeth, J.D. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem 279, 4737-42 (2004).

Chi, Y., Zhou, B., Wang, W.-Q., Chung, S.-K., Kwon, Y.-U., Ahn, Y.-H., Chang, Y.-T., Tsujishita, Y., Hurley, J.H. and Zhang, Z.-Y. Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatases SPsynaptojanin and SHIP2. J. Biol. Chem. M406416200 (2004).

Chua, J. and Deretic, V. Mycobacterium tuberculosis Reprograms Waves of Phosphatidylinositol 3-Phosphate on Phagosomal Organelles. J. Biol. Chem. 279, 36982-36992 (2004).

Corgan, A.M., Singleton, C., Santoso, C.B. & Greenwood, J.A. Phosphoinositides differentially regulate alpha-actinin flexibility and function. Biochem J 378, 1067-72 (2004).

Davis, A.J., Perera, I.Y. and Boss, W.F. Cyclodextrins enhance recombinant phosphatidylinositol phosphate kinase activity. J. Lipid Res. 45, 1783-1789 (2004).

Dove, S.K., Piper, R.C., McEwen, R.K., Yu, J.W., King, M.C., Hughes, D.C., Thuring, J., Holmes, A.B., Cooke, F.T., Michell, R.H., Parker, P.J., & Lemmon, M.A. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. The EMBO Journal, 1-12 (2004).

Du, X., H. Zhang, et al. (2004). "Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators." J Biol Chem 279(36): 37271-81.

Dunn, R., D. A. Klos, et al. (2004). "The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo." J Cell Biol 165(1): 135-44.

Ellena, J.F., Moulthrop, J., Wu, J., Rauch, M., Jaysinghne, S., Castle, J.D. and Cafiso, D.S. Membrane Position of a Basic Aromatic Peptide that Sequesters Phosphatidylinositol 4,5 Bisphosphate Determined by Site-Directed Spin Labeling and High-Resolution NMR. Biophys. J. biophysj.104.046748 (2004).

Ercetin, M. E. and G. E. Gillaspy (2004). "Molecular characterization of an Arabidopsis gene encoding a phospholipid-specific inositol polyphosphate 5-phosphatase." Plant Physiol 135(2): 938-46.

Flaxenburg, J. A., M. Melter, et al. (2004). "The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase." J Immunol 172(12): 7503-9.

Fuster, D., O. W. Moe, et al. (2004). "Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods." Proc Natl Acad Sci U S A 101(28): 10482-7.

Gambhir, A., Hangyas-Mihalyne, G., Zaitseva, I., Cafiso, D.S., Wang, J., Murray, D., Pentyala, S.N., Smith, S.O. & McLaughlin, S. Electrostatic Sequestration of PIP(2) on Phospholipid Membranes by Basic/Aromatic Regions of Proteins. Biophys J 86, 2188-207 (2004).

Gamper, N., Reznikov, V., Yamada, Y., Yang, J. and Shapiro, M.S. Phosphotidylinositol 4,5-Bisphosphate Signals Underlie Receptor-Specific Gq/11-Mediated Modulation of N-Type Ca2+ Channels. J. Neurosci. 24, 10980-10992 (2004).

Hayes, M.J., Merrifield, C.J., Shao, D., Ayala-Sanmartin, J., Schorey, C.D., Levine, T.P., Proust, J., Curran, J., Bailly, M. & Moss, S.E. Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway. J Biol Chem 279, 14157-64 (2004).

He, F., Mao, M. & Wensel, T.G. Enhancement of phototransduction g protein-effector interactions by phosphoinositides. J Biol Chem 279, 8986-90 (2004).

Hernandez-Hansen, V., Smith, A.J., Surviladze, Z., Chigaev, A., Mazel, T., Kalesnikoff, J., Lowell, C.A., Krystal, G., Sklar, L.A., Wilson, B.S. and Oliver, J.M. Dysregulated Fc{epsilon}RI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells. J. Immunol. 173, 100-112 (2004).

Hirdes, W., Horowitz, L.F. and Hille, B. Muscarinic modulation of erg potassium current. J. Physiol. 559, 67-84 (2004).

Hiromura, M., Okada, F., Obata, T., Auguin, D., Shibata, T., Roumenstand, C. and Noguchi, M. Inhibition of Akt kinase activity by a peptide spanning the beta A strand of the protooncogene TCL1. J. Biol. Chem. M403775200 (2004).

Hirono, M., Denis, C.S., Richardson, G.P. and Gillespie, P.G. Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation. Neuron 44, 309-20 (2004).

Hyun, T.S., Rao, D.S., Saint-Dic, D., Michael, L.E., Kumar, P.D., Bradley, S.V., Mizukami, I.F., Oravecz-Wilson, K.I. & Ross, T.S. HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. J Biol Chem 279, 14294-306 (2004).

Iijima, Y., Gang, D.R., Fridman, E., Lewinsohn, E. & Pichersky, E. Characterization of geraniol synthase from the peltate glands of sweet basil. Plant Physiol 134, 370-9 (2004).

Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F. & Devreotes, P.N. Novel Mechanism of PTEN Regulation by Its Phosphatidylinositol 4,5-Bisphosphate Binding Motif Is Critical for Chemotaxis. J Biol Chem 279, 16606-13 (2004).

Jun, Y., Fratti, R.A. and Wickner, W. Diacylglycerol and Its Formation by Phospholipase C Regulate Rab- and SNARE-dependent Yeast Vacuole Fusion. J. Biol. Chem. 279, 53186-53195 (2004).

Kitamura, T., Y. Kitamura, et al. (2004). "Mosaic analysis of insulin receptor function." J Clin Invest 113(2): 209-19.

Kobayashi, M., Mutharasan, R.K., Feng, J., Roberts, M.F. and Lomasney, J.W. Identification of hydrophobic interactions between proteins and lipids: free fatty acids activate phospholipase C delta1 via allosterism. Biochemistry 43, 7522-33 (2004).

Kondo, T. and Kahn, C.R. Altered insulin signaling in retinal tissue in diabetic States. J Biol Chem 279, 37997-8006 (2004).

Kutateladze, T.G., Capelluto, D.G., Ferguson, C.G., Cheever, M.L., Kutateladze, A.G., Prestwich, G.D. & Overduin, M. Multivalent mechanism of membrane insertion by the FYVE domain. J Biol Chem 279, 3050-7 (2004).

Lacalle, R.A., Gomez-Mouton, C., Barber, D.F., Jimenez-Baranda, S., Mira, E., Martinez-A., C., Carrera, A.C. and Manes, S. PTEN regulates motility but not directionality during leukocyte chemotaxis. J. Cell Sci. 117, 6207-6215 (2004).

Le Blanc, C., Mironneau, C., Barbot, C., Henaff, M., Bondeva, T., Wetzker, R. and Macrez, N. Regulation of Vascular L-type Ca2+ Channels by Phosphatidylinositol 3,4,5-Trisphosphate. Circ. Res. 95, 300-307 (2004).

Lee, S.B., Varnai, P., Balla, A., Jalink, K., Rhee, S.G. & Balla, T. The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme. J Biol Chem 279, 24362-71 (2004).

Lee, S.J. and Montell, C. Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron 43, 95-103 (2004).

Lee, S. J., H. Xu, et al. (2004). "Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila." Proc Natl Acad Sci U S A 101(32): 11874-9.

Lee, S.Y., Wenk, M.R., Kim, Y., Nairn, A.C. and De Camilli, P. Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A 101, 546-51 (2004).

Lee, T.K., Man, K., Ho, J.W., Sun, C.K., Ng, K.T., Wang, X.H., Wong, Y.C., Ng, I.O., Xu, R.R. and Fan, S.T. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis bgh250 (2004).

Lim, K.P. and Hong, W. Human Nischarin/Imidazoline Receptor Antisera-selected Protein Is Targeted to the Endosomes by a Combined Action of a PX Domain and a Coiled-coil Region. J Biol Chem 279, 54770-82 (2004).

Lindsay, A.J. and McCaffrey, M.W. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. J. Cell Sci. 117, 4365-4375 (2004).

Liu, H., Radisky, D.C., Wang, F. & Bissell, M.J. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol 164, 603-12 (2004).

Luo, B., Prescott, S.M. & Topham, M.K. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal 16, 891-7 (2004).

Martin, D.M., Faldt, J. and Bohlmann, J. Functional Characterization of Nine Norway Spruce TPS Genes and Evolution of Gymnosperm Terpene Synthases of the TPS-d Subfamily. Plant Physiology 135, 1908-1927 (2004).

McDonald, E.R., 3rd and El-Deiry, W.S. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. Proc Natl Acad Sci U S A 101, 6170-5 (2004).

Merino-Trigo, A., Kerr, M.C., Houghton, F., Lindberg, A., Mitchell, C., Teasdale, R.D. and Gleeson, P.A. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation. J Cell Sci 117, 6413-24 (2004).

Nagata, Y., K. H. Lan, et al. (2004). "PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients." Cancer Cell 6(2): 117-27.

Nigorikawa, K., Okamura, N. and Hazeki, O. The effect of anionic amphiphiles on the recruitment of rac in neutrophils. J Biochem (Tokyo) 136, 463-70 (2004).

Olsten, M.E.K., Canton, D.A., Zhang, C., Walton, P.A. and Litchfield, D.W. The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane. J. Biol. Chem. 279, 42114-42127 (2004).

Ortiz, P.A., Hong, N.J. and Garvin, J.L. Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90. Am J Physiol Renal Physiol 287, F281-288 (2004).

Pagliarini, D.J., Worby, C.A. and Dixon, J.E. A PTEN-like Phosphatase with a Novel Substrate Specificity. J. Biol. Chem. 279, 38590-38596 (2004).

Park, H. S., S. H. Lee, et al. (2004). "Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2." Mol Cell Biol 24(10): 4384-94.

Peterman, T.K., Ohol, Y.M., McReynolds, L.J. and Luna, E.J. Patellin1, a Novel Sec14-Like Protein, Localizes to the Cell Plate and Binds Phosphoinositides. Plant Physiology pp.104.045369 (2004).

Plattner, R., Koleske, A.J., Kazlauskas, A. and Pendergast, A.M. Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor. Mol. Cell. Biol. 24, 2573-2583 (2004).

Prestwich, G.D. Phosphoinositide signaling; from affinity probes to pharmaceutical targets. Chem Biol 11, 619-37 (2004).

Prestwich, G. D. (2004). "Visualizing signalling by phosphoinositide 3-kinase pathway lipids." Biochem Soc Trans 32(Pt 2): 336-7.

Poliquin, K., Ershov, Y.V., Cunningham, F.X., Jr., Woreta, T.T., Gantt, R.R. and Gantt, E. Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro. J. Bacteriol. 186, 4685-4693 (2004).

Rajala, R. V., M. E. McClellan, et al. (2004). "Interaction of the retinal insulin receptor beta-subunit with the P85 subunit of phosphoinositide 3-kinase." Biochemistry 43(19): 5637-50.

Redfern, D.A. & Gericke, A. Domain formation in phosphatidylinositol monophosphate/phosphatidylcholine mixed vesicles. Biophys J 86, 2980-92 (2004).

Rousset, M., Cens, T., Gouin-Charnet, A., Scamps, F. & Charnet, P. Ca2+ and phosphatidylinositol 4,5-bisphosphate stabilize a Gbeta gamma-sensitive state of Ca V2 Ca 2+ channels. J Biol Chem 279, 14619-30 (2004).

Rudge, S.A., Anderson, D.M. & Emr, S.D. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Mol Biol Cell 15, 24-36 (2004).

Safi, A., M. Vandromme, et al. (2004). "Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation." Mol Cell Biol 24(3): 1245-55.

Sbrissa, D., Ikonomov, O.C., Strakova, J. and Shisheva, A. Role for a Novel Signaling Intermediate, Phosphatidylinositol 5-Phosphate, in Insulin-Regulated F-Actin Stress Fiber Breakdown and GLUT4 Translocation. Endocrinology 145, 4853-4865 (2004).

Schubert, M., Gautam, D., Surjo, D., Ueki, K., Baudler, S., Schubert, D., Kondo, T., Alber, J., Galldiks, N., Kustermann, E., Arndt, S., Jacobs, A.H., Krone, W., Kahn, C.R. and Bruning, J.C. Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 101, 3100-5 (2004).

Schulz, T.A. & Creutz, C.E. The tricalbin C2 domains: lipid-binding properties of a novel, synaptotagmin-like yeast protein family. Biochemistry 43, 3987-95 (2004).

Seidel, R.D., 3rd, Amor, J.C., Kahn, R.A. and Prestegard, J.H. Structural perturbations in human ADP ribosylation factor-1 accompanying the binding of phosphatidylinositides. Biochemistry 43, 15393-403 (2004).

Shi, H., I. Tzameli, et al. (2004). "Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling." J Biol Chem 279(33): 34733-40.

Simonsen, A., Birkeland, H.C.G., Gillooly, D.J., Mizushima, N., Kuma, A., Yoshimori, T., Slagsvold, T., Brech, A. and Stenmark, H. Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J. Cell Sci. 117, 4239-4251 (2004).

Skowronek, K. R., F. Guo, et al. (2004). "The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor Trio in binding to phospholipids." J Biol Chem.

Smith, T.J. and Hoa, N. Immunoglobulins from Patients with Graves' Disease Induce Hyaluronan Synthesis in Their Orbital Fibroblasts through the Self-Antigen, Insulin-Like Growth Factor-I Receptor. J. Clin. Endocrinol. Metab. 89, 5076-5080 (2004).

Soughayer, J.S., Wang, Y., Li, H., Cheung, S.H., Rossi, F.M., Stanbridge, E.J., Sims, C.E. and Allbritton, N.L. Characterization of TAT-mediated transport of detachable kinase substrates. Biochemistry 43, 8528-40 (2004).

Stolt, P.C., Vardar, D. and Blacklow, S.C. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry 43, 10979-87 (2004).

Stratford, S., Hoehn, K.L., Liu, F. and Summers, S.A. Regulation of Insulin Action by Ceramide: DUAL MECHANISMS LINKING CERAMIDE ACCUMULATION TO THE INHIBITION OF Akt/PROTEIN KINASE B. J Biol Chem 279, 36608-15 (2004).

Stromhaug, P.E., Reggiori, F., Guan, J., Wang, C.-W. and Klionsky, D.J. Atg21 Is a Phosphoinositide Binding Protein Required for Efficient Lipidation and Localization of Atg8 during Uptake of Aminopeptidase I by Selective Autophagy. Mol. Biol. Cell 15, 3553-3566 (2004).

Sumitomo, M., Iwase, A., Zheng, R., Navarro, D., Kaminetzky, D., Shen, R., Georgescu, M.M. and Nanus, D.M. Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell 5, 67-78 (2004).

Sun, C.X., Downey, G.P., Zhu, F., Koh, A.L.Y., Thang, H. and Glogauer, M. Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104, 3758-3765 (2004).

Sweeney, G., Garg, R.R., Ceddia, R.B., Li, D., Ishiki, M., Somwar, R., Foster, L.J., Neilsen, P.O., Prestwich, G.D., Rudich, A. and Klip, A. Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. J Biol Chem 279, 32233-42 (2004).

Testa, C. A., R. M. Cornish, et al. (2004). "The sorbitol phosphotransferase system is responsible for transport of 2-C-methyl-D-erythritol into Salmonella enterica serovar typhimurium." J Bacteriol 186(2): 473-80.

Tholl, D., C. M. Kish, et al. (2004). "Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases." Plant Cell 16(4): 977-92.

Tong, Q., Gamper, N., Medina, J.L., Shapiro, M.S. & Stockand, J.D. Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase. J Biol Chem 279, 22654-63 (2004).

Tronchere, H., Laporte, J., Pendaries, C., Chaussade, C., Liaubet, L., Pirola, L., Mandel, J.L. & Payrastre, B. Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells. J Biol Chem 279, 7304-12 (2004).

Tsujita, K., Itoh, T., Ijuin, T., Yamamoto, A., Shisheva, A., Laporte, J. & Takenawa, T. Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. J Biol Chem 279, 13817-24 (2004).

Voynova, N.E., Rios, S.E. & Miziorko, H.M. Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway. J Bacteriol 186, 61-7 (2004).

Wang, Y.J., Li, W.H., Wang, J., Xu, K., Dong, P., Luo, X. and Yin, H.L. Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signaling. J Cell Biol 167, 1005-10 (2004).

Wild, A.C., Yu, J.W., Lemmon, M.A. & Blumer, K.J. The p21-activated Protein Kinase-related Kinase Cla4 Is a Coincidence Detector of Signaling by Cdc42 and Phosphatidylinositol 4-Phosphate. J Biol Chem 279, 17101-10 (2004).

Xiang Sun, C., Downey, G.P., Zhu, F., Koh, A.L., Thang, H. and Glogauer, M. Rac1 is the small GTPase Responsible for Regulating the Neutrophil Chemotaxis Compass. Blood 2004-03-0781 (2004).

Xing, Y., D. Liu, et al. (2004). "Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX)." J Biol Chem 279(29): 30662-9.

Yu, J.W., Mendrola, J.M., Audhya, A., Singh, S., Keleti, D., DeWald, D.B., Murray, D., Emr, S.D. & Lemmon, M.A. Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol Cell 13, 677-88 (2004).

Zhang, C., Baker, D.L., Yasuda, S., Makarova, N., Balazs, L., Johnson, L.R., Marathe, G.K., McIntyre, T.M., Xu, Y., Prestwich, G.D., Byun, H.S., Bittman, R. & Tigyi, G. Lysophosphatidic Acid Induces Neointima Formation Through PPAR{gamma} Activation. J Exp Med 199, 763-774 (2004).

2005

An, H., Xu, H., Zhang, M., Zhou, J., Feng, T., Qian, C., Qi, R. and Cao, X. Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through phosphatase activity- and PI-3K-independent mechanism. Blood 2005-01-0191 (2005).

Ano, Y., Hattori, T., Oku, M., Mukaiyama, H., Baba, M., Ohsumi, Y., Kato, N. and Sakai, Y. A Sorting Nexin PpAtg24 Regulates Vacuolar Membrane Dynamics during Pexophagy via Binding to Phosphatidylinositol-3-Phosphate. Mol. Biol. Cell 16, 446-457 (2005).

Bernal, C., Mendez, E., Terencio, J., Boronat, A. and Imperial, S. A spectrophotometric assay for the determination of 4-diphosphocytidyl-2-C-methyl-d-erythritol kinase activity. Anal Biochem 340, 245-51 (2005).

Cao, X., Kambe, F., Moeller, L.C., Refetoff, S. and Seo, H. Thyroid Hormone Induces Rapid Activation of Akt/Protein Kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3-Kinase in Human Fibroblasts. Mol. Endocrinol. 19, 102-112 (2005).

Chang, J.S., Kim, S.K., Kwon, T.K., Bae, S.S., Min do, S., Lee, Y.H., Kim, S.O., Seo, J.K., Choi, J.H. and Suh, P.G. Pleckstrin Homology Domains of Phospholipase C-{gamma}1 Directly Interact with {beta}-Tubulin for Activation of Phospholipase C-{gamma}1 and Reciprocal Modulation of {beta}-Tubulin Function in Microtubule Assembly. J Biol Chem 280, 6897-905 (2005).

Hutchinson, D.S. and Bengtsson, T. {alpha}1A-Adrenoceptors Activate Glucose Uptake in L6 Muscle Cells through a Phospholipase C-, Phosphatidylinositol-3 Kinase-, and Atypical Protein Kinase C-Dependent Pathway. Endocrinology 146, 901-912 (2005).

Johnson, L.M., James, K.M., Chamberlain, M.D. and Anderson, D.H. Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity. Biochemistry 44, 3432-3440 (2005).

Kagawa, S., Sasaoka, T., Yaguchi, S., Ishihara, H., Tsuneki, H., Murakami, S., Fukui, K., Wada, T., Kobayashi, S., Kimura, I. and Kobayashi, M. Impact of SH2-Containing Inositol 5'-Phosphatase 2 Gene Polymorphisms Detected in a Japanese Population on Insulin Signaling. J. Clin. Endocrinol. Metab. jc.2004-1724 (2005).

Kanda, H., Tamori, Y., Shinoda, H., Yoshikawa, M., Sakaue, M., Udagawa, J., Otani, H., Tashiro, F., Miyazaki, J.-i. and Kasuga, M. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J. Clin. Invest. 115, 291-301 (2005).

Kostenko, E.V., Mahon, G.M., Cheng, L. and Whitehead, I.P. The Sec14 Homology Domain Regulates the Cellular Distribution and Transforming Activity of the Rho-specific Guanine Nucleotide Exchange Factor Dbs. J Biol Chem 280, 2807-17 (2005).

Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M. and Ingraham, H.A. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120, 343-55 (2005).

Lin, Y., Kimpler, L.A., Naismith, T.V., Lauer, J.M. and Hanson, P.I. Interaction of the Mammalian Endosomal Sorting Complex Required for Transport (ESCRT) III Protein hSnf7-1 with Itself, Membranes, and the AAA+ ATPase SKD1. J Biol Chem 280, 12799-809 (2005).

Punjabi, A. and Traktman, P. Cell Biological and Functional Characterization of the Vaccinia Virus F10 Kinase: Implications for the Mechanism of Virion Morphogenesis. J. Virol. 79, 2171-2190 (2005).

Rider, C.V., Gorr, T.A., Olmstead, A.W., Wasilak, B.A. and LeBlanc, G.A. Stress signaling: coregulation of hemoglobin and male sex determination through a terpenoid signaling pathway in a crustacean. J. Exp. Biol. 208, 15-23 (2005).

Sanchez, T., Thangada, S., Wu, M.T., Kontos, C.D., Wu, D., Wu, H. and Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A 102, 4312-7 (2005).

White, E.S., Atrasz, R.G., Dickie, E.G., Aronoff, D.M., Stambolic, V., Mak, T.W., Moore, B.B. and Peters-Golden, M. Prostaglandin E2 Inhibits Fibroblast Migration by E-Prostanoid 2 Receptor-Mediated Increase in PTEN Activity. Am. J. Respir. Cell Mol. Biol. 32, 135-141 (2005).

Lee, T.K., Man, K., Ho, J.W., Sun, C.K., Ng, K.T., Wang, X.H., Wong, Y.C., Ng, I.O., Xu, R.R. and Fan, S.T. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis bgh250 (2004).