Isoprenoids and Isoprenols are key metabolic intermediates for biosynthesis of steroids, including cholesterol and hormones that regulate human reproduction or fertility, and posttranslational modifications of proteins in signal transduction pathways for cell division and regulation of vesicular trafficking. 2Z,6Z-Farnesyl diphosphate is synthesized by Z-farnesyl diphosphate synthase (M. tuberculosis) from neryl diphosphate. It is not a substrate for protein-farnesyl transferase. |
