Biliverdin Hydrochloride is produced from the oxidation of heme in a reaction catalyzed by the enzyme heme oxygenase¹.  Heme oxygenase has been implicated in tumor cell resistance to chemotherapy², reduction of free radical formation³, reduction of inflammation⁴ and has been associated with vascular repair⁴.  In vivo biliverdin is reduced to bilirubin.  Biliverdin Hydrochloride is soluble in basic aqueous solutions (pH > 9 for intitial dissolution) and soluble down to pH 7 once in solution as well as methanol and ethanol if made slightly basic.