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Product Name
Akt Inhibitor (KP372-1)
Catalog Number
B-0102
Unit Price
$220.00
Quantity
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| KP372-1 directly inhibits the kinase activities of Akt, PDK1 and Flt3 (Fms-like tyrosine kinase 3), which are aberrantly activated in acute myelogenous leukemia (AML). It is a cell permeant inhibitor that decreases the colony-forming ability of AML cells (IC50 < 200 nM) with minimal cytoxic effects on normal hematopoietic progenitor cells. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in thyroid cancer cells and gliobastoma. |
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| Formula: |
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—C10H4N6O, FW: 224.2 (1:1 mixture of isomers)
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| Solubility: |
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—Water: insoluble, DMSO: 5 mg/mL
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| Storage: |
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—dry between 2-8oC. Stock solutions should be stored frozen (-20oC).
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| References: |
—Br. J. Cancer, 2005
—Cancer Res.,2006
—Mol. CncerTther., 2006
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| Catalog: |
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—Inhibitors
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