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       Category : Assays :   PI3-Kinase Assay : PI3-K gamma Inhibitor 2 (AS604850)
     Category :   Inhibitors : PI3-K gamma Inhibitor 2 (AS604850)
     Category : Inhibitors :   PI 3-Kinase Inhibitors : PI3-K gamma Inhibitor 2 (AS604850)



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5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione is a selective inhibitor of PI 3- Kã with an IC50 = 250 nM. It is selective for the ã-isoform (IC50: PI 3-Ká = 4.5 uM, PI 3-Kâ, PI 3-Kä > 20 uM) and shows no notable activity against a wide array of protein kinases at 1 mM.
Formula:
—C11H7F2NO4S, FW: 287.2
Solubility:
—water: insoluble, DMSO: 5 mg/mL
Storage:
—store dry between 2-8oC. Stock solutions should be stored frozen (-20oC).
References:
Nature Medicine, 2005
Catalog:
PI3-Kinase Inhibitors
 
Additional Informaiton
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B-0302