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       Category : Phosphoinositide Reagents and Derivatives :   Metabolically Stabilized Phosphoinositides : PtdIns(3,4,5)P3 3-phosphothioate, diC16 (3S-PtdIns(3,4,5)P3 , diC16)



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Synthetic PI(3,4,5)3 analogs in which the 3-phosphate bond has been rendered metabolically stable as a phosphoithioate. P-3S916 increases sodium transport across monolayers of cells A6 through activation of GLUT4. P-3S908 shows 90% inhibition of PTEN at 0.4µM.

—Synthesis and Biological Activity of PTEN-Resistant Analogues of Phosphtidylinositol 3,4,5-triphosphate
— J. Am. Chem. Soc. 128, 16464-16465, 2006
MW :
—1242.4
Formula :
—C45H111N7O21P4S
Solubility :
—H2O, 0.5 mg/mL
 
Additional Informaiton
  --
 P-3S916
 
 
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