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Product Name
ERK1, active
Catalog Number
E-K073U
Unit Price
$315.00
Quantity
10.0 ug
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Recombinant full-length, tag-free human ERK1 was expressed in Sf 9 cells and activated by active MEK1 in vitro. The gene accession number is NM_002746.
This material is sold for research purposes only. |
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| Scientific Background: |
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—ERK1 is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines (1). Activation of ERK1 requires both tyrosine and threonine phosphorylation that is mediated by MEK. ERK1 is ubiquitously distributed in tissues with the highest expression in heart, brain and spinal cord. Activated ERK1 translocates into the nucleus where it phosphorylates various transcription factors (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP beta).
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| Storage: |
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—Store product frozen at or below -70°C. Stable for 1 year at -70°C as undiluted stock. Aliquot to avoid repeated thawing and freezing.
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| References: |
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—1. Boulton, TG. et al: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. Biochemistry. 1991 Jan 8; 30(1): 278-86.
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