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       Category : Phosphoinositide Reagents and Derivatives :   Metabolically Stabilized Phosphoinositides : PtdIns(4,5)P2 a-fluorophosphonate, diC16 (ms-PtdIns(4,5)P2 diC16)



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"Synthetic PI(4,5)P2 analogs in which the phosphodiester bond has been rendered metabolically stable via the a-fluorophosphonate. P-F4508 restores the TRPM4 ion channel current at similar concentrations as diC8-PI(4,5)P2. Ref: H. Zhang et al. 'Synthesis and Biological Activity of Phospholipase C-Resistant Analogues of Phosphatidylinositol 4,5-bisphosphate' /J. Am. Chem. Soc/. /128/, 5642-5643, *2006*"

 

 

Solubility =:
—H2O, 0.2 mg/mL 1:1 CHCl3:MeOH 1 mg/mL
MW = :
—1072.2
Formula = :
—C42H97FN5O18P3
 
Additional Informaiton
  --
P-F4516