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Product Name
PLA2 Substrate, DBPC
Catalog Number
L-3000
Unit Price
$206.00
Quantity
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| The PLA2 substrate, DBPC (catalog # L-3000), is a sensitive probe for a continuous fluorogenic detection applicable to both /in vitro/ and cell-based /in situ/ screening assays
Phospholipase A2 (PLA2) is the enzyme which cleaves phospholipids to produce lysophospholipids and free fatty acids. The PLA2 family of enzymes is known to be at least 10 distinct members. sPLA2-V and sPLA2-X are selectively expressed in human airway epithelium and sPLA2-X in various immune cells. The basal expression of a third enzyme, sPLA2-IIA is low but becomes highly expressed during inflammation and sepsis. This enzyme has become associated with allergic rhinitis, rheumatoid arthritis, septic shock and ARDS. PLA2-IIA represents a target for the treatment of inflammatory disease. |
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| Storage: |
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—-80 °C
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| Featured in Publication: |
—Chemistry & Biology, July 2002
—ACS Chemical Biology, March 2006
—Journal of Biological Chemistry, 2006
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