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Product Name
PTEN enzyme
Catalog Number
E-3000
Unit Price
$108.00
Quantity
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| Description: |
—N-Terminal GST-Tagged, recombinent human PTEN (Phosphatase and Tensin Homolog), 76kD, purified from E.coli using glutathione-sepharose column chromatography.
PTEN is a 3 phosphoinosited phosphatase that converts PI(3,4,5)P3 back to PI(4,5)P2 thus opposing PKB/Akt activation by PI 3-K. PTEN is involved in neuronal stem call proliferation and self-renewal, cardiac myocyte hypertrophy and contractility, and a wide range of developmental processes. PTEN, however, is best known for its role as a tumor suppressor. Loss of PTEN activity results in accumulation of PI(3,4,5)P3, abnormal activation of PKB/Akt, unregulated cell growth, suppression of apoptosis, and increase tumorigenesis in a number of human tissues. It has also been proposed that PTEN is a candidate for targeted chemotherapy because certain anti-cancer agents preferentially destroy tumors with PTEN mutations. In addition to this direct role in cancer, PTEN also indirectly regulates cancer-associated pathways including VEGF-mediated angiogenesis among others.
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—Negative 70 C
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| Related Products: |
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—PTEN; PTEN ELISA Kit: K-2300; Malachite Green Assay Kit: K-1500, K-1520, K-1530, K-1540; PTEN Substrate: P-3908, P-3916, Q-1345, H-39BT, H-39TM, H-39FL; Other Lipid Phosphatase: E-1000 (SHIP2)
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| Catalog: |
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—PTEN Enzyme
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