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Product Name
PTEN ELISA
Catalog Number
K-2300
Unit Price
$411.00
Quantity
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| 96 well ELISA kit measures PTEN activity.
PTEN activity has been implicated as a tumor suppressor in several different cancers. In adipose tissue, insulin controls glucose and lipid metabolism through the intracellular mediators phosphatidylinositol 3-
kinase and serine-threonine kinase AKT. Phosphatase and a tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase / AKT pathway, is hypothesized to inhibit
the metabolic effects of insulin. Results demonstrate that in vivo PTEN is a potent negative regulator of insulin signaling and insulin sensitivity in adipose tissue. Furthermore, PTEN may be a promising target for nutritional and/or pharmacological interventions aimed at reversing insulin resistance. |
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| Benefits: |
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—10-100 times more sensitive than current assays- Uses 10-100 times less enzyme- Directly measures PTEN product
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| Storage: |
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—2-8 °C, Do not freeze thaw multiple times
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| Applications: |
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—Screening compounds for inhibition of PTEN activity- Determination of PTEN activity - Screen tumor cell lines for PTEN activity
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| Catalog: |
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—PTEN
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